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Effect of Comestibles on Symptoms of Interstitial Cystitis

Effect of Comestibles on Symptoms of Interstitial Cystitis. Background. Interstitial cystitis “ pelvic pain, pressure, or discomfort related to the bladder, typically associated with persistent urge to void or urinary frequency, in the absence of infection or other pathology ”.

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Effect of Comestibles on Symptoms of Interstitial Cystitis

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  1. Effect of Comestibles on Symptoms of Interstitial Cystitis

  2. Background Interstitial cystitis “pelvic pain, pressure, or discomfort related to the bladder, typically associated with persistent urge to void or urinary frequency, in the absence of infection or other pathology” Rev Urol 2007 Spring;9(2):81

  3. Definition • National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) 1988 consensus definition • European Society for the Study of IC-PBS (ESSIC) 2006 consensus meeting • Washington, DC, Consensus Group on Interstitial Cystitis-Painful Bladder Syndrome (IC-PBS)

  4. Prevalence • In NHANES III, the prevalence was 470 per 100,000 population, including 60 per 100,000 men and 850 per 100,000 women. • This equals approximately 83,000 men and 1.2 million women across the U.S. American Urological Association (AUA) Guideline (2011)

  5. More than 180 therapies are used to treat PBS/IC with no single modality successful for all patients. • Rovner E, et al: Urology 2000; 56: 940.

  6. Factors such as stress, medication,allergic reactions, sexual intercourse, hormonal changes anddiet may exacerbate bladder symptoms. Barbara Shorter, et al; J Urol. 2007 Jul;178(1):145-52.

  7. Gap • Specific diet really induce exacerbation of BPS ? esp. in Taiwanese / Asians ? • Taiwanese / Asians have the same “high risk comestibles” as the western society? • Age or BPS scores of BPS patients related to possibility of “high risk comestibles”?

  8. Significance • The only Taiwanese / Asian data in the world • Determine some diets really induce exacerbation of BPS • Answer what diets cause Taiwanese exacerbation of BPS • Analysis relationship between “Age or BPS scores of BPS patients” and “high risk comestibles”

  9. Methods • 藉由一份通過驗證的問卷，統整約30項國外已知可能會惡化間質性膀胱炎的食物，訪談大林慈濟醫院婦產科患有間質性膀胱炎的婦女。 • 採病例對照研究、立意取樣收集100位，自2013年9月始，達研究目標樣本為止。 • 間質性膀胱炎病人回婦產科許鈞碩醫師門診追蹤時，經由許鈞碩醫師進行知情同意，之後進行電話問卷。

  10. 預期結果

  11. Odds ratio • 危險對比值 (odds ratio) = (暴露組中得病人數與未得病人數之比值) / (非暴露組中得病人數與未得病人數之比值)

  12. 吃特定食物會比不吃還要容易惡化間質性膀胱炎嗎？吃特定食物會比不吃還要容易惡化間質性膀胱炎嗎？ 吃特定食品會造成症狀惡化的危險對比值 (odds ratio) = (較頻繁地暴露在特定食物中且症狀分數較高的病人數，與較頻繁地暴露在特定食物中且症狀分數較低的病人數之比值) (較不常暴露在特定食物中且症狀分數較高的病人數，與較不常暴露在特定食物中且症狀分數較低的病人數之比值)

  13. 年紀越大越有可能飲食中暗藏會惡化膀胱症狀的食物嗎？年紀越大越有可能飲食中暗藏會惡化膀胱症狀的食物嗎？ 年紀大小和"可能有會惡化膀胱症狀食物的潛質"的危險對比值 (odds ratio) = (年紀較大且有任何食物會惡化症狀的病人數，與年紀較大且無任何食物會惡化症狀的病人數之比值) (年紀較小且有任何食物會惡化症狀的病人數，與年紀較小且無任何食物會惡化症狀的病人數之比值))

  14. 症狀越嚴重，越有可能飲食中暗藏會惡化膀胱症狀的食物嗎？症狀越嚴重，越有可能飲食中暗藏會惡化膀胱症狀的食物嗎？ 症狀分數和"可能有會惡化膀胱症狀食物的潛質"的危險對比值 (odds ratio) = (症狀分數較高且有任何食物會惡化症狀的病人數，與症狀分數較高且無任何食物會惡化症狀的病人數之比值)/ (症狀分數較低且有任何食物會惡化症狀的病人數，與症狀分數較低且無任何食物會惡化症狀的病人數之比值)

  15. 台灣間質性膀胱炎病人應避免的食物 • … • … • …

  16. Thanks for your attention!

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