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The Damage and Repair of DNA

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The Damage and Repair of DNA. Two main types of DNA damage: *point mutations *structural changes. The molecular basis of point mutations. 1. Base substitution (mismatches) transition transversion. 2. Tautomeric shift. Gene Mutation. The molecular basis of point mutations.

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Presentation Transcript
slide1

The Damage and Repair of DNA

Two main types of DNA damage:

*point mutations

*structural changes

The molecular basis of point mutations

1. Base substitution (mismatches)

transition

transversion

2. Tautomeric shift

slide2

Gene Mutation

The molecular basis of point mutations

3. Base analogs and chemical mutagens

slide3

DNA Damage

The molecular basis of structural damage

1. Hydrolytic damage

Deamination

N-glycosidic bond – very weak and easily broken

Depurination

Deamination

slide4

DNA Damage

The molecular basis of structural damage

2. Alkylation

slide5

DNA Damage

The molecular basis of structural damage

3. Oxidation and Radiation

slide6

Repairing Damages Bases

1. Mismatch repair (MMR)

Dam methylase:

MutS:

slide7

Repairing Damages Bases

1. Mismatch repair (MMR)

slide8

Repairing Damages Bases

2. Photoreactivation

slide9

Repairing Damages Bases

3. Repair of alkylation

slide10

(BER)

Repairing Damages Bases

4. Base excision repair (BER)

slide11

Repairing Damages Bases

4. Base excision repair (BER)

slide12

Repairing Damages Bases

5. Nucleotide excision repair (NER)

slide13

DNA Repair

7. Double Strand Break Repair (DSB)

Nonhomologous End-Joining (NHEJ)

Ku

XRCC4

DNA-PKcs

Artemis

Ligase

slide14

DNA Repair

8. Double Strand Break (DSB) repair (Homologous Recombination)

slide15

DNA Repair

8. Double Strand Break (DSB) repair (Homologous Recombination)