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Biocompatible Dextran coated Nanoceria with pH dependent Antioxidant properties

Introduction • Nanoceria is a potent free radical scavengers with neuroprotective, radioprotective, anti-inflammatory property and exhibits unique autocatalytic activity. • Most of these studies have been done with nanoparticles with poor hydrophilicity or involving

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Biocompatible Dextran coated Nanoceria with pH dependent Antioxidant properties

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  1. Introduction • Nanoceria is a potent free radical scavengers with neuroprotective, radioprotective, anti-inflammatory property and exhibits unique autocatalytic activity. • Most of these studies have been done with nanoparticles with poor hydrophilicity or involving use of toxic solvents, limiting potential clinical use. • We report a facile synthesis of monodisperse, water soluble and highly crystalline dextran-coated nanoceria (DNC). • DNC exhibits unique pH-dependent antioxidant activity, allowing important applications in the design of improved therapeutics. A. R. Asati and J. M. Perez Nanoscience Technology Center, Department of Chemistry, and Burnett College of Biomedical Sciences, University of Central Florida, 12424 Research Parkway, Suite 400, Orlando, FL 32826. Biocompatible Dextran coated Nanoceria with pH dependent Antioxidant properties Confirmation of Dextran Coating Biological studies FT-IR DLS Concanavallin-A Characterization Cell Viability Assays Results and Conclusion • Biocompatible DNC exhibits excellent pH- dependent antioxidant properties for improved cancer therapeutics.. • Other potential applications include development of antioxidant and anti-inflammatory coatings in prosthetic devices and tissue engineering and their use in supramolecular materials. • In summary, results support the potential use of DNC as smart, pH- dependent therapeutic agents and devices that selectively protect healthy tissue from free radicals, which are elevated during chronic inflammation or upon radiotherapy or chemotherapy. Synthesis A solution containing cerium (III) nitrate and dextran T-10 was added drop-wise to ammonium hydroxide solution and stirred for 24 h at 25 ºC. The color of solution changed from light yellow to dark brown indicating the formation of stabilized dextran-coated ceria nanoparticles. Afterwards, the solution was centrifuged to settle down any debris and large agglomerates. Finally, the centrifuged solution was purified from free dextran and concentrated using an amicon cell and stored at 4 ºC. a.TEM b. HR-TEM c.XRD d. XPS e. DLS f. Concentration Autocatalytic Activity of DNC at pH 7.4 and pH 4.0 Acknowledgement This work was supported in part by NCI grant CA101781 and by a UCF-NSTC Start-Up Fund, all to Dr. J. M. Perez. Reference J. M. Perez, A. Asati, S. Nath, C. Kaittanis. “Synthesis of biocompatible dextran-coated nanoceria with pH-dependent antioxidant properties.” Small, Jan 2008.

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