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IMPLEMENTATION

IMPLEMENTATION. José A. Bengoechea. Kick-off meeting Palma Mallorca January 24th 2013. INBIONET TIMELINE. Submission……………… 11/01/2012 [15:14:49] Invitation to negotiation…… 7/05/2012 21/05/2012 (first draft Annex I)

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IMPLEMENTATION

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  1. IMPLEMENTATION José A. Bengoechea Kick-off meeting Palma Mallorca January 24th 2013

  2. INBIONET TIMELINE Submission………………11/01/2012 [15:14:49] Invitation to negotiation……7/05/2012 21/05/2012 (first draft Annex I) Annex I accepted by REA………18/7/2012 GA signature by REA…......11/09/2012 Project officer Mattia Zilli 1st of January 2013

  3. INBIONET partners will combine their experience and expertise to deliver a state-of-the-art Research Programme in the competitive field of “microbial anti-immunology” with the goal of identifying novel therapies based on modulating the host-pathogen interaction. • Research On the whole, it is expected that this training programme will provide the recruited scientists with the scientific and complementary skills they will need for a successful career in the field of “microbial anti-immunology” either in academia or industry. • Training

  4. WP1 INNATE RESPONSES Lead: TCD • Tasks are projects ESR1-ESR7; ER1-ER2 • Annual report submitted to Supervisory Board • Milestones M1: Implementation of cellular models to analyze the activation of PRRs M2: Implementation cellular models to analyze the activation of IFN • Deliverables D1: Identification PRRs and PAMPs responsible for defense responses; D2: Viral and bacterial means to subvert type I IFN production, D3: Identification pathways suitable for immunomodulation

  5. WP2 PATHOGEN REPLICATION Lead: MFPL • Tasks are projects ESR8-ESR11; ER3-ER4 • Annual report submitted to Supervisory Board • Milestones M1:Implementation in vivo models to measure mucosal immunity M2: Implementation in vivo models to manipulate mucosal immunity • Deliverables • D1: Bacterial intracellular survival strategies; • D2: IFN control ofviruses and bacteria replication, • D3:In vivo strategies for immunomodulation

  6. WP3 TRAINING Lead: EPFL • Training Committee • Tasks • Embedding an ESR/ER into a research group. • Preparation of Personal Development Plan. • Establishment of INBIONET ESR/ER committees. • Monitoring and reviewing of the work plan and timelines (12 months). • Organization of TUs, including network workshops. • Organization of rotations between laboratories. • Organization of training sections of the network meetings. • Annual report submitted to Supervisory Board

  7. WP3 TRAINING Lead: EPFL • Milestones M1: Affiliation Graduate Schools M2: Personal Development Plan • M3: INBIONET ESR/ER committees • M4: Training units and network workshops* • M5: Rotations* • Deliverables • D1: ESR/ER personal career plans*; • D2: Research fellows progress reports*, • D3: Training units and network workshops*

  8. WP3 TRAINING Lead: EPFL • Local level • Graduate Schools • Local courses/seminars • Language courses • Network level • INBIONET web page • International meetings • Training units (TUs) • Network workshops (NWs) • Network meetings (NMs) • Secondments • Final INBIONET conference

  9. WP3 TRAINING Lead: EPFL

  10. WP3 TRAINING Lead: EPFL TU1Experimental techniques of manipulation of innate immune signaling by pathogens at the cellular level. TCD, collaboration FISIB Dublin (M7) • On-hands course on pathogen manipulation of innate immune signaling cascades at the cellular levels • Offered ONLY to INBIONET fellows plus partners´ fellows (places available)

  11. WP3 TRAINING Lead: EPFL NW 1Advanced topics in innate immune signaling TCD, collaboration FISIB Dublin (M7) • 2 days lectures (keynote speakers), posters and oral presentations • Offered to INBIONET fellows plus institutions´ fellows (places available) Gender issues: female speakers (magical figure of 40%) Outreach sesion: “The host-pathogen arms race: stories from the front line”

  12. WP3 TRAINING Lead: EPFL TU2Animal models in inflammation, animal care and animal imaging. MPFL, Vienna (M9) • Competence on animal techniques and experimental models useful for inflammatory and infectious diseases (including ethical issues). • Offered ONLY to INBIONET fellows plus partners´ fellows (places available)

  13. WP3 TRAINING Lead: EPFL NW 2Animal models in inflammation and infection MPFL Vienna (M9) • 2 days lectures (keynote speakers), posters and oral presentations • Offered to INBIONET fellows plus institutions´ fellows (places available) Gender issues: female speakers (magical figure of 40%) Outreach sesion: ‘How infectious diseases change human life’.

  14. WP3 TRAINING Lead: EPFL TU3Identification and functional characterization of innate immune cells in mucosal tissues. EPFL, collaboration Preclin Lausanne (M18) • On-hands course on analysis of mucosal innate immune responses. • Offered ONLY to INBIONET fellows plus partners´ fellows (places available)

  15. WP3 TRAINING Lead: EPFL NW 3 Mucosal immunology EPFL, collaboration Preclin Lausanne (M7) • 2 days lectures (keynote speakers), posters and oral presentations • Offered to INBIONET fellows plus institutions´ fellows (places available) Gender aspects: female speakers (magical figure of 40%) Outreach sesion: Mice, amoebas, flies and worms helping research’.

  16. WP3 TRAINING Lead: EPFL TU4-NW4Know-how transfer and entrepreneurship. ParcBit, collaboration FISIB Palma Mallorca (M27) • Process of company creation in the European biotechnology sector. • Offered ONLY to INBIONET fellows plus partners´ fellows (places available) Gender aspects: female speakers (magical figure of 40%) Outreach sesion: “Translational medicine: from the lab to the company to the bed”.

  17. WP3 TRAINING Lead: EPFL TU5 Complementary skills ParcBit, collaboration FISIB Linked to the Network meetings • Offered ONLY to INBIONET fellows plus partners´ fellows (places available) • scientific communication skills; NM1-3 • how to write scientific applications; NM3 • career planning and job hunting; NM2-3 • laboratory/group management. NM3 Keynote speaker ???

  18. WP3 TRAINING Lead: EPFL Secondments • At least 2 per fellow • Academia and industry and vicerversa • At least 2 months, “fixed period” 1. IP (2 months, within M18-M24) to assess the modulation of ubiquitination by Klebsiella spp. 2. Sanofi (4 months, within M26-M36) In vivo pneumonia model tagging bacteria and host molecules.

  19. WP4 SCIENCE and SOCIETY Lead: USTAN • Tasks: • Advertising of INBIONET activities • Preparation and dissemination of INBIONET E-Newsletter. • INBIONET video clips. • Maintenance of INBIONET web page as open access resource of data. • Dissemination via social media (Twitter and Blog). • Establishment and maintenance of links with national Microbiology/Immunology Societies and local Graduate schools. • Establishment and maintenance of contacts with European research initiatives. (INFECT-ERA) • Outreach activities. • Development of an agenda for long lasting collaborations between academic research groups and industry.

  20. WP4 SCIENCE and SOCIETY Lead: USTAN • Deliverables • D1:Social media accounts (Twitter, Blog)*; • D2: E-Newsletter *, • D3: INBIONET Video-clips *

  21. WP4 SCIENCE and SOCIETY Lead: USTAN Outreach activities: • Twitter (@INBIONET) • INBIONET Blog (each fellow 2 post per yr) • Outreach reports (each fellow 2 per yr) • E-Newsletter (every 6 months) • INBIONET clips (each fellow 2) • Outreach sessions workshops

  22. WP5 MANAGEMENT Lead: FISIB • Tasks: • Organization of the kick-off meeting • Development of the INBIONET web site • Recruitment • Organization of the Network meetings (agenda, speakers,…) • Monitoring and evaluation of the WPs´ progress reports. • Organization of the mandatory Mid-term review.

  23. WP5 MANAGEMENT Lead: FISIB Supervisory Board • S trategic decision-making body • Formed by all partners and chaired by coordinator • Meeting once per yr during Network meetings • Consensus-voting rules (2/3 quorum; simple majority)

  24. WP5 MANAGEMENT Lead: FISIB Training committee • Responsible training programme, gender issues • TCD, MPFL, EPFL, ParcBit, FISIB, Preclin, Sanofi, one ESR (female) • Meeting once per yr during Network meetings • Consensus-voting rules (2/3 quorum; simple majority)

  25. WP5 MANAGEMENT Lead: FISIB Recruitment committee • Responsible recruitment, employment, gender issues • TCD, FISIB, EPFL, IP, Preclin • Meeting once per yr during Network meetings • Consensus-voting rules (2/3 quorum; simple majority)

  26. WP5 MANAGEMENT Lead: FISIB Patenting committee • Responsible exploitation issues, protection of intellectual property • FISIB, Preclin, Sanofi, ParcBit, IP • According to Consortium Agreement • Meeting once per yr during Network meetings • Consensus-voting rules (2/3 quorum; simple majority)

  27. WP5 MANAGEMENT Lead: FISIB Coordinator Partners Fellows Project manager Committee chairs Work package leaders Supervisory Board Work package leaders submit annual progress report

  28. WP5 MANAGEMENT Lead: FISIB Management meetings Kick-off meeting: Palma de Mallorca, hosted by FISIB (M1) 1st Network meeting: Vienna (Austria), hosted by MFPL (M12) 2nd Network meeting: Paris, hosted by IP (M21; mid-term review) 3rd Network meeting: Berlin, hosted by MPIIB (M30) 4th Final conference: Palma de Mallorca, hosted by FISIB and ParcBit (M41)

  29. RECRUITMENT • Early Stage Researchers (ESR) • No PhD • Research experience ≤ 4* years • 36 months • Experienced Researchers (ER) still in their early career • PhD or Research experience ≥ 4* years AND • Research experience ≤ 5* years • 24 months • * counted from the diploma that gives the rights to embark in a doctoral degree

  30. RECRUITMENT

  31. RECRUITMENT 40% female researchers

  32. RECRUITMENT

  33. RECRUITMENT

  34. RECRUITMENT

  35. RECRUITMENT ….Teleconference coordinator… • Personal career development plan • Declaration of conformity • INBIONET ESR committee Supervisor+colaborator+other ESR selected (non collaborator) • INBIONET ER committee Supervisor+other ER selected

  36. …Reports for Commission…

  37. …Reports for INBIONET… Annual progress report evaluated by INBIONET ESR/ER committee Oral presentation evaluated by INBIONET ESR/ER committee

  38. GENDER ASPECTS • 40% of fellows • Keynote speakers (aiming 40%) • ESR appoint to Training committee will be female • Monitoring actions • Recruitment committee for working related • Training committee for training related

  39. PROJECT MONITORING Periodic and final reports are contractual deliverables • Research activities • Training activites • Management activities • Dissemination activities

  40. IMMEDIATE ACTIONS • Committees • Recruitment call • Consortium Agreement • Animal permissions • Budget transfer …going for dinner…

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