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Planar Microelectrode Arrays Hardware, Software & Algorithms New Tools for Drug Discovery. Tom Manuccia Professor Department of Electrical & Computer Engineering George Washington University 202-994-9298 manuccia@gwu.edu. DESCRIPTION:

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planar microelectrode arrays hardware software algorithms new tools for drug discovery

Planar Microelectrode ArraysHardware, Software & AlgorithmsNew Tools for Drug Discovery

Tom Manuccia

ProfessorDepartment of Electrical & Computer EngineeringGeorge Washington University202-994-9298 manuccia@gwu.edu

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DESCRIPTION:

    • Build high throughput system to detect effects of drugs under development on the firing patterns of nerve cells grown in culture. Build the system around a new type of microelectrode array developed in my lab over the past 5 years.
  • NEED:
    • Huge market. Every candidate compound must be extensively tested for neurotoxic effects.
  • STATE-OF-THE-ART:
    • All sequential experiments - One drug, one concentration, no simultaneous control
  • INNOVATION:
    • 96 or more simultaneous toxicology experiments possible using Optically Switched Microelectrode Array (OSMA) technology - Vastly increased throughput
  • PROJECT SCOPE (1st three years):
    • Build 3 prototype systems (hardware, software & consumables) & install in selected beta test sites
  • MARKET
    • Estimated Market Size (next 10 years): 10 systems in each of the 10 largest pharmaceutical labs
    • Pricing: Other high throughput testing systems giving similar value added sell for $5 M each.
    • % Market Capture: Zero for 1st 3 years; 10% per year thereafter
      • Source of market estimates: Meetings with VP level staff at Glaxo, Merck, J&J, & Eli Lilly
    • Cost of Production (incl. amortized R&D costs): $1 M / system
      • Source of research, development and production cost data: Actual expenditures from my lab