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Development of ECM-Based Wound Healing Patch

Design an off-the-shelf band-aid type wound repair patch incorporating Extracellular Matrix (ECM) to promote cell migration, growth, and reduce scarring. Explore live cell incorporation for large wounds and assess shelf-life of the patch.

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Development of ECM-Based Wound Healing Patch

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  1. Design a wound healing patch incorporating Extracellular matrix

  2. Advisor(s): Affiliation: Contact: Prof. Sakthikumar Ambady BME, WPI sambady@wpi.edu 508-831-5714 Team size: 3-4 students Area of study : Tissue engineering Expertise required: Cell culture, Decellularization, Microscopy

  3. Project need Use of decellularized tissue patches is an effective strategy for wound repair. Natural ECM allows native cells to migrate and repopulate the wounded area. This project envisages the development an off-the-shelf band aid type of device using ECM, preferably incorporating reagents that enhance healing, and reduce scarring

  4. Project Goal (a) Design and develop an off-the-shelf band-aid type wound repair patch that incorporates ECM (b) Evaluate the efficacy of the device to support cell migration, cell growth (c) Explore the possibility of incorporating live cells on the patches to repair large wounds (d) Evaluate shelf-life of the patch

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