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Veterinary Biocontained facility Network

H2020-INFRAIA-2016-2017 Integrating and opening research infrastructure of European interest. Veterinary Biocontained facility Network for excellence in animal infectiology research and experimentation Coordinators : Frédéric Lantier, Sascha Trapp

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Veterinary Biocontained facility Network

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  1. H2020-INFRAIA-2016-2017 Integrating and opening research infrastructure of European interest Veterinary Biocontained facility Network for excellence in animal infectiology research and experimentation Coordinators: Frédéric Lantier, Sascha Trapp UMR 1282 ISP, Infectiologie et Santé Publique INRA, Centre Val-de-Loire, Tours-Nouzilly, France

  2. Project Call: EC – Horizon 2020EuropeanResearch Infrastructures (2016-2017) • Integrating and opening infrastructures of European interest • "Integrating activities for Starting Communities" - whose research infrastructures show a limited degree of coordination and networking at present • - 5 Millions Euros -. • "Integrating activities for Advanced Communities" – whose research infrastructures show an advanced degree of coordination and networking at present, in particular, through Integrating Activities awarded under previous Framework Programmes. • The Commission considers that proposals requesting a contribution from the EU of up to EUR 10 million would allow this topic to be addressed appropriately. • Deadline March 30, 2016

  3. HORIZON 2020 – WORK PROGRAMME 2016-2017 European research infrastructures An Infrastructure project shall combine, in a closely coordinated manner: • Networking activities, to foster a culture of co-operation between research infrastructures, scientific communities, industries and other stakeholders as appropriate, and to help developing a more efficient and attractive European research area. Typically 20% of total amount (i.e. 2 M€). • Joint research activities,to improve, in quality and/or quantity, the integrated servicesprovided at European level by the infrastructures. Typically 40% of total amount (i.e. 4 M€), including management (about 0,5 M€). • Trans-national access plus virtual access activities, to support scientific communities in their access to the identified research infrastructures; Typically 40% of total amount (i.e. 4 M€). All three categories of activities are mandatory as synergistic effects are expected from these different components.

  4. Control of infectious diseases: a societal challenge • “ONE HEALTH” • SUSTAINABLE AGRICULTURE • ANIMAL HEALTH • FOOD SAFETY • HUMAN HEALTH COORDINATION OF EUROPEAN RESEARCH INFRASTRUCTURES ON ANIMAL INFECTIOLOGY, INCLUDING ZOONOSIS

  5. Experimentalinfectiology

  6. The TOPIC (Biological and Medical Sciences) • The TOPIC related to and build upon the principal goals of NADIR, the Network for Animal Diseases Infectiology Research (2009-2013). • “High-containment biosafety facilities for animal disease and infectiology (including zoonoses). A project under this topic has to: • Provide and facilitate access to the key experimental facilities under BSL3 conditions in Europe for animal and zoonotic infectious diseases. • Include key collections of samples necessary for research on animal and zoonotic infectious diseases. • Aim to integrate these facilities and resources with a long term perspective. • Develop the necessary collaborations outside Europe, towards a global sharing of available resources.”

  7. Project Structure relate to main points of the callLead of Work-Packages distributedamongpartners!

  8. The VetBioNet consortium Kenya 19 Academic 1 – INRA 2 – CVI 3 – FLI 4 – TPI 5 – APHA 6 – MRI 7 – INIA 8 – IRTA 9 – EDI-IVI 10 – PIWET 11 – MS 12 – AU 13 – ANSES 14 – UEDIN (RI) 15 – EMC 16 – IZSVe 17 – UNOTT 18 – UCD International organisations 19 – ILRI • 20– AAHL (CSIRO) • 21 – PIADC • 22 – CFIA • 23 – EAAP Industry -SMEs 24 – Inscreenex 25 – Leica 26 – Noldus 27 – Epibiosafe 28 – VAL 29 – Ingenasa 30 – INRA Transfert Australia 20 USA 21 Canada 22 28 11 14 6 12 18 3 17 2 26 24 5 15 10 4 25 27 13 30 1 9 16 23 8 29 7 21

  9. Experimental facilities for animal disease and infectiology (including zoonoses) • Core partners: provide access to BSL3 animal experimental facilities (and laboratories), infected samples and live animal resources. • Complementary partners:provide access to state-of-the-art technical platforms (molecular analytics – imaging), tools and sample archives; provide expertise for the design and realisation of animal infectious disease studies (e.g. ethics (UNOTT), Omic tools (UCD)) or communication tools (EAAP). • Industrial partners, SMEs: contribute to improve the technical standard of the consortium facilities and tools for experimentation and/or data analyses, technical development and eventually commercialisation. • Associated partners :provide complementary expertise in high containment facility management and epidemics (CSIRO, PIADC, CFIA, ILRI, … CODA-SERVA) • Stakeholders: • Information on emergences (OIE, WHO, FAO, …) • Information on pathogens (EVAg, MIRRI, …) • Networks related to infectious diseases (EPIZONE, CoFund One Health, SAPHIR, IDOH …) • Industries and breeders

  10. Governance and advisors’ committee • Coordinator (F. Lantier, INRA): Overall project coordination; acts as the intermediary between the project partners, the project manager, the Management WP leader (Sascha Trapp, INRA), and the European Commission • Executive Committee (ExCom):Decision-implementing body of the project (chaired by the Coordinator, 10 WP leaders and 2 private partner representatives) • Governing Council (GC):Decision-making body of the project (chaired by the Coordinator, 1 representative per project partner) • User Selection Panel (USP):review and selection of TNA projects (8 scientists from outside the consortium) • Stakeholder Advisory Board (SAB):advises the consortium on strategic project adjustments (6 representatives from key stakeholder organisations) • Stakeholder Platform: stakeholder entry port to the project; principal dissemination instrument (list of Stakeholders managed by the WP5 leader). • Intellectual Property Use and Dissemination Committee (IPUDC): advises the consortium on IP and technical transfer related issues (6 lawyers and/or technology transfer experts from different partner organisations)

  11. Trans-National Access and Networking Activities Overall objective: To foster a culture of co-operation between research infrastructures, scientific communities, industries and other stakeholders,and to promote European research related to animal infectious diseases WP1: Promote and facilitate Transnational Accessto the infrastructure resources (14 confined animal facilities, plus laboratories, technological platforms and sample collections = TNA 11 – 31) WP2: Enhance the preparedness of the major European BSL3 research infrastructures to respond to (re)emerging epizootic and zoonotic threats(emergency plan with dedicated funding) WP3: Share resources, harmonize Best Practicesand promote the use of global standards in European BSL3 infrastructures WP4: Ensure high ethical standardsand clarify the social impact of VetBioNet research work WP5: Ensure proper dissemination of the project objectives and outputs to stakeholders, provide training opportunities, and manage the ensemble of project related data (open data) WP6: Develop and implement a Sustainability Plan for the network to continue beyond the five-year term of funding

  12. WP1: Free access to VetBioNet infrastructures! Submit a proposal : http://www.vetbionet.eu/calls/ Permanent Call for TransNational Access (2018-2020) Selectedproposalswill have free access to one or evenseveralfacilitiesamong the 21 VetBioNet Partners’ infrastructures Proposal leader shouldbefrom a country (including non-european countries) otherthan the one of the requested infrastructure Proposalleader shouldNot befrom a VetBioNet partner lab.

  13. Transnational Access (TNA) portfolio 16 consortium partners(INRA, CVI, FLI, TPI, APHA, MRI, INIA, IRTA, EDI-IVI, PIWET, MS, AU, ANSES, RI, EMC, IZSVe) 21 TNA WPs Access to BSL3 animal experimentalfacilities– 14 partners Access to (non-)confinedlaboratories and platforms for high-end sample analyses (OMICS, opticalimaging, bioimaging etc.) – 16 partners Access to sample collections (tissues, nucleicacids, pathogens etc.) – 10 partners Generation of "Sampleson demand" (links with1-3) – 7 partners Access to live animal ressources – 4 partners

  14. WP2: preparedness plan for (re)emergingdisease A BSL3 facility Directors consultation group called “Veterinary Emerging Threat Response Group” (VETRG) has been set up in M16 (D2.1; M16). The VETRG is the central instrument of the VetBioNet Preparedness Plan. Its role is to: • Develop and adopt a preparedness plan in case of (re-)emerging infectious disease outbreaks; • Provide recommendations on the use of emergency resources, notably the project’s Emergency Fund (EF); • Devise strategies on the interactive use of animal facilities; • Exchange information on current / planned emerging pathogen studies in animals; • Eventually structure and prioritize work topics and animal studies; • Inform EU strategies for BSL3 animal experimentation specialisation for the future.

  15. Joint researchactivities Joint Research Activities are designed to improve the scientific and technological standards of the integrated services provided by the network infrastructures: • WP7:Develop novel or optimise existing animal infection models for OIE notifiable infectious diseases and emerging diseases. Develop alternatives to experiments on living animals: Cell Culture, Explants and Organoids. • WP8: Develop novel analytical tools, protocols, and reagents for improved analyses of host-pathogen interactions • WP9: Develop imaging and telemetric tools and protocols for the monitoring and evaluation of clinical and pathological outcomes of experimental infections

  16. Stakeholder Advisory Board To help adapting the project objectives according to environmental and epidemiologic changes during the VetBioNet life (5 years). Roles • Provides an external point of view on the project overall progress • Introduce stakeholder requirements (opinions and constraints) in the development of VetBioNet technologies and end products • Propose changes to the direction of the project in line with stakeholder and end-user priorities for maximising the exploitation and benefits for the industry • Review progress of the project annually. Composition The following members have agreed to participate: • Jan Langermans, Biomedical Primate Research Center, BPRC • Giovanni Migliaccio, European infrastructure for translational medicine, EATRIS • EranRaizman, Food Agriculture Organisation, FAO • Antonino Caminiti, World Organisation for Animal Health, OIE

  17. Stakeholder Platform Composition to be completed • List of contacts managed by EAAP (WP5 on dissemination), Gary Entrican (WP 6 on Sustainability and WP10 (Sascha Trapp, Management). • Representatives from all stakeholders with an interest in the project: • Researchers in animal infectiology • Funding bodies • Policy-makers and international organisations • Research networks and working groups • Farmers and agri-food industry • Animal pharma and veterinary companies, SME Roles • Preferential contacts for the dissemination of project outcomes to society and for consultation by the partners on specific issues where the input from stakeholders is needed: first meeting in Brussel (2017, Nov 27-28).

  18. VetBioNetbenefitsfor partners and scientists Project partners: • NAs: Active role in the 6 NA WPs, collaboration toolkits; project meetings • Stakeholder Platform: Outreach to industrial Stakeholders and international organisations or research initiatives • JRAs:Active role in the 3 JRA WPs; providing samples for molecular analyses and imaging (WPs 8/9); eligible to propose projects related to emerging outbreaks (WP2) • TNA (providing): Enhanced use/impact of infrastructure resources. • TNA (requesting): Partners are Noteligible, but can provide contribution to projects coordinated by external users. Individual scientists and students (Project partners/External researchers): • Training opportunities: Summer courses, virtual trainings, Webinar series, and E-learning platform – links to the IDOH Master programme (WP5)

  19. CONTACTS

  20. INRAMétaprogramme GISA (Gestion Intégrée de la Santé des Animaux) Coordination : INRA-ISP, Val-de-Loire Nouzilly Fabrice Laurent et Frédéric Lantier Santé Animale Coordination : INRA Frédéric Lantier et Sascha Trapp

  21. UneInfrastructure Nationale Distribuée de Recherchepour la lutte contre les maladies infectieuses animales émergentes ou zoonotiques L’INRA a pris l’initiative de fédérer les établissements de recherche (INRA, CIRAD), d’enseignement (ENV) et l’agence nationale d’expertise (ANSES) compétents en matière de recherche et d’analyse de risque sur les maladies émergentes ayant des impacts en santé des animaux et en santé publique vétérinaire Une construction basée sur les acquis des INFRAstructures Européennes : • NADIR, Network for Animal DiseasesInfectiologyResearch(coord INRA, 2009-2013) • VetBioNet, VeterinaryBiocontainedfacility Network for excellence in animal infectiologyresearch and experimentation(Coord. INRA, F Lantier, S. Trapp, 2017- 2021) Et sur la complémentarité des Infrastructures : • INRA : PFIE, CIRE, IERP • CIRAD : Insectarium et IE Montpellier • ANSES : Ploufragan et Nancy

  22. Des complémentarités historiques et fonctionnelles • PFIE (Nouzilly) –PF Exp. en confinement (BSL2 et 3) • ISP-PFIE : Imagerie en confinement : de l’animal corps entier à la cellule • CIRE : Imagerie corps entier (IRM, CT-scan, Cellvisio…) • IERP (Jouy-en-Josas) : • Laboratoire de référence • Maladies à déclaration obligatoire • Installations expérimentales Porc et Volailles (Ploufragan) • Installations et expertise Faune sauvage (Nancy) • Maladies tropicales Vectorisées • Insectarium : élevage et infection d’insectes • Microscopie en confinement • Réseau partenariats en zone tropicales

  23. Un panel de services pour la recherche et l’innovation en infectiologie • Mettre à disposition et développer un panel de services pour la recherche et l’innovation en infectiologie, en matières de diagnostic, vaccination, thérapeutiques anti-infectieuses et gestion sanitaire des cheptels. • Diffuser les savoir et les savoir-faire au sein des réseaux existants et dans le cadre de la formation des utilisateurs et des étudiants • Développer le Partenariats public-privé : experte et ouverte, l’infrastructure nationale sera un instrument de développement : • Dans le secteur existant du diagnostic et du médicament vétérinaire • Dans le secteur émergent des innovations en « BIOCONTROLE » des agents infectieux en élevage : validation expérimentale des produits et stratégies de maîtrise non-médicamenteuses d’agents infectieux. • Une communauté d’experts légitimes pour la lisibilité de la France à l’international : le projet H2020 VetBioNet piloté par la France (INRA) réussit d’ores et déjà à fédérer et animer la communauté des infrastructures internationales compétentes en santé publique vétérinaire et santé animale,

  24. Merci de votre attention ! D

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