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Moisture Content Determination

The presence of moisture will affect the chemical and physical properties of the final product. Excessive moisture can cause the powder particles to agglomerate and make the tablets brittle. Too little moisture can cause tablets to scatter. Learn more at https://www.formulationbio.com/moisture-content-determination.html

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Moisture Content Determination

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  1. Moisture Content Determination The presence of moisture will affect the chemical and physical properties of the final product. Excessive moisture can cause the powder particles to agglomerate and make the tablets brittle. Too little moisture can cause tablets to scatter. Powdered excipients may not flow if they are too wet, and some active pharmaceutical ingredients (API) may crystallize or change form if there is too much moisture. The production method of solid dosage form includes freeze-drying, fluidized bed drying, compaction, granulation and extrusion. All of these operations depend on the amount of moisture present and the state, moisture also affects the chemical/physical properties of individual active ingredients and excipients. Therefore, accurate determination of moisture content is very important to ensure the quality of drugs. Fig.1 Common types of contact drying equipment. CD Formulation can provide you with moisture content determination services of APIs and inactive ingredients, and our scientists will help you to make a decision for operational and procedural conditions that can ensure the

  2. physical and chemical stability and pharmacological activity of the product to minimize potential formulation and stability issues. Moisture Sources of Dosage Forms •Bulk drug •Manufacturing processes •Inactive excipients •Environmental conditions Our Methods for Moisture Content Determination Methods Drying methods Direct determination Absorption of water in a suitable drying agent (desiccant is measured before and after absorption) Indirect determination - mass loss of the sample Drying of the samples under precisely defined conditions -, methods in an oven method Exposing the sample to dry atmosphere (as in a desiccator)

  3. Method with NIR (Near Infrared Reflectance) analyzer Routine methods Method with NIT (Near Infrared Transmission) analyzer Deliverable •Data analysis •Provide full study report Source: https://www.formulationbio.com/moisture-content-determination.html

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