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Samper et al. Hptal Defensa, Madrid

VESICAL INSTILLATIONS OF HA REDUCE THE ACUTE VESICAL TOXICITY INDUCED BY HIGH DOSE BRACHYTHERAPY ESTRO Congress Goteborg , 2008. Samper et al. Hptal Defensa, Madrid.

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Samper et al. Hptal Defensa, Madrid

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  1. VESICAL INSTILLATIONS OF HA REDUCE THE ACUTE VESICAL TOXICITY INDUCED BY HIGH DOSE BRACHYTHERAPYESTRO CongressGoteborg , 2008 Samper et al. Hptal Defensa, Madrid

  2. AfterRadiotherapyforpelvictumorsthepathologicalchanges are very similar tothoseon PBS/IC95 Patientssufferingfrom Cervical or Endometrial cancerweretreatedwithBrachytherapy (BQT) withorwithoutCystistatinstillations 70’5% Endometrial cancer 28’4% Cervical cancer 1’1% Vaginal cancerInstillation 30 min. Prior toeach BQT session

  3. 48 HA Group 95 patients 47 UC Group 60 monthsfollow-upRates of acute and late vesical toxicitywererecorded in bothgroups: Vesical toxicity Grade 2 or more:HA Group: 2’08% UC Group: 12’80%

  4. Acute vesical toxicity:WK 1WK2WK3WK4WK5WK6HA Group 8’3 20’8 16’7 10’9 14’7 0UC Group 19’1 40’4 31’9 31’9 33’3 27’3

  5. Late vesical toxicity:M3 M6 M12 M18 M24 M30 M36 M48 M60 HA Group8’9 7’5 0 0 0 0 0 0 04/45 3/40 0/33 0/28 0/23 0/21 0/17 0/13 0/4UC Group19’0 13’5 10’3 8’7 10’5 5’6 7’1 11’1 33’3 8/42 5/37 3/29 2/23 2/19 1/18 1/14 1/9 1/3

  6. Conclusion:Vesical instillations of HA decreasetheincidence and thedegree of acute vesical toxicityinducedbyhighdosebrachytherapy and reduce thepercentage of patientsthatdeveloptoxicity of degree 2 or more

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