Nanomedicine. Jonathan P. Rothstein. Introduction. What is nanomedicine ? It is nanotechnology used for the treatment, diagnosis, monitoring and control of biological systems
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Jonathan P. Rothstein
vascular, bladder and neural applications
Biomedical Analysis and Communication System
Disposable Diagnostic BioChip
Breast Cancer Cells
A: Scanning electron microscope of a dried 10-μm-diameter colloidosome composed of 0.9- μm-diameter polystyrene spheres.
[Pickering (1907); Pieranski PRL 45, 569 (1980)]
I. Particle (P) away from interface:
Interfacial Area = A
Energy = AgO/W + 4pR2gP/O
II. Particle sitting astride the interface (half-in, half-out):
Energy = (A-pR2)gO/W + 2pR2gP/O+ 2pR2gP/W
Standard Diffusion Based Drug Delivery
Nano-Encapsulated Drug Delivery
Drug Concentration in Patient
Important to tissue engineering:Cells will differentiate purely based on mechanical stimulus.
Genzyme ACT method: FDA approved 1997
Through Addition of Nanoparticles
Khaled et al. Biomaterials (2003)