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Nitric Oxide in Health, Disease, and Therapeutics

N. O. Nitric Oxide in Health, Disease, and Therapeutics. Daniel Kim-Shapiro Department of Physics and Translational Science Center. NO deficiency contributes to much pathology and it can be used to treat many diseases. NO improves cardiovascular function Vasodilator

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Nitric Oxide in Health, Disease, and Therapeutics

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  1. N O Nitric Oxide in Health, Disease, and Therapeutics Daniel Kim-Shapiro Department of Physics and Translational Science Center

  2. NO deficiency contributes to much pathology and it can be used to treat many diseases • NO improves cardiovascular function • Vasodilator • Inhibits platelet aggregation • Anti-inflammatory (reduce ROS) • Rescue endothelial dysfunction (aging) • Treatment for pulmonary hypertension • Protective against ischemic reperfusion injury • Deficient in hemolytic conditions (incl stored blood) Wake Forest University

  3. Discovery that Nitrite Vasodilates Cosby et al, Nature Med., 2003 Wake Forest University

  4. Nitrite Therapeutics Sickle Cell Disease Chronic vascular disease

  5. Nitrite Therapy via Nitrate Intake

  6. Nitrate Diet and Physical/Cognitive Functional Health This is your brain Low High This is your brain on nitrite Wake Forest University

  7. “Have you heard about beet juice? The blood-red elixir of the beet is apparently the hottest thing for Olympic athletes looking for a non-illegal performance boost. Soon the world will be caught up in beet juice fever. Too bad it tastes like "sweet dirt.“”

  8. Current Projects Hemolysis: NO, platelets and ROS Further Studies in Hemoglobin Nitrite reactivity Develop compounds to treat Hemolysis Study nitrite in older adults and disease Improve blood transfusion and develop blood substitutes Wake Forest University

  9. Tools Quantum Gravitational Fragility Tester 3000

  10. Kim-Shapiro Lab and Associates Wake Forest University

  11. Funding Wake Forest University

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