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WALKER BIOLOGY CLUB MEETING & GUEST SPEAKER!!. Dr. Janice Swab, a world-traveling evolutionary biologist will be speaking! Come hear about “Following Darwin [and not following Darwin] in the Southern Hemisphere!” January 23, 2008 5:00 p.m. in Room 210. Pizza & Drinks Provided!. Announcements.

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WALKER BIOLOGY CLUB MEETING & GUEST SPEAKER!!

Dr. Janice Swab, a world-traveling evolutionary biologist will be speaking!

Come hear about “Following Darwin [and not following Darwin] in the Southern Hemisphere!”

January 23, 2008

5:00 p.m. in Room 210

Pizza & Drinks Provided!


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Announcements

  • Topics for paper due today!

    • Pick a number

    • When signing up for your topic announce to the class what it is so that they know what has been taken.

  • Begin literature search!

    • Locate a minimum of 1 review article & 2 peer reviewed research articles.

    • Type out a reference list & have a copy of the papers turned in by Feb 4!

    • Worth a 10 pt quiz grade.


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Innate Immunity

An Overview


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The interaction of Mf with pathogens


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What PRProteins & receptors are on the Mf?

  • Mf Mannose Receptor:

    • C-type Lectin (PRP)

    • Binds mannose, N acetylglucosamine, & fucose residues on pathogen surface molecules.


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  • Scavenger Receptors:

    • Group of @ least 6 molecular forms.

    • Recognize lipoproteins on Gm + & Gm – bacteria.

    • Involved in elimination of old & apoptotic cells.

  • Glucan receptor-

    • Dectin-1: C-type lectin (PRP)

    • Binds b-glucans (LPS)


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  • LPS Receptor

    • Works with the Toll Like Receptors to stimulate cytokine production in the macrophage.

Toll Like Receptors-

- Recognize different component of pathogens.

- Associates with other receptor & involved with signal transduction.

  • CR3- Opsonization.


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How do phagocytes kill the pathogens?

  • 1. Acidification of the phagosome- ATP Synthase

If activated, the mf will undergo a respiratory burst & phago-lysosomal fusion occurs.


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  • 2.Oxygen dependent killing mechanisms:

    • A) Enzymes to make Reactive oxygen radicals (ROIs):

      • NADPH oxidase- phagosomal membrane

        • Multicomplex protein.

        • Reduction of O2 superoxide anion (O2-):

      • SOD: converts superoxide to H2O2

      • Myeloperoxidase- lysosomal protein

        • Produces Hypochlorous acid (OCl-) & Hydroxyl Radicals.


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B) Reactive Nitrogen Intermediates (RNIs).

  • nitric oxide synthetase (NOS):

    • NO can be easily converted to peroxynitrite anion & nitrogen dioxide.

NADPH

NADP


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3. Oxygen-Independent Killing mechanisms:

Hydrolytic enzymes:

Lysozyme

Proteases

RNases & DNases.

Defensins:

cationic peptides (cysteine); 29-35 AA.

Competitors-

Lactoferrin- compete cells for iron



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1- Increase in vascular diameter.

2- Increase in vascular permeability

3- Endothelial cells activated to express adhesion molecules.

inflammation.


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