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sensor.neusc.bcm.tmc/David/Book.html

Powerpoint slides from “Mechanisms of Memory”. http://sensor.neusc.bcm.tmc.edu/David/Book.html. Class Web site (should be up next week) http://www.biology.ucsd.edu/classes/bipn148.SP05 Office hours: Aryn Gittis Tues 5:30-6:30; Wed 11-12 Pac Hall 1115 Danny Simpson Mon 11-12 CLICS 2nd Floor.

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sensor.neusc.bcm.tmc/David/Book.html

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  1. Powerpoint slides from “Mechanisms of Memory” http://sensor.neusc.bcm.tmc.edu/David/Book.html Class Web site (should be up next week) http://www.biology.ucsd.edu/classes/bipn148.SP05 Office hours: Aryn Gittis Tues 5:30-6:30; Wed 11-12 Pac Hall 1115 Danny Simpson Mon 11-12 CLICS 2nd Floor

  2. Ebbinghaus Results

  3. Ebbinghaus Test continued (Further analysis of short and long-term memory) Indicate A-L or M-Z Indicate M/F Physical Activity: H/L (H=3 times a week, > 30 minutes each)

  4. Ebbinghaus Test 1 continued Write: Delay=48 h Write down as many of the words you remember from Monday

  5. Ebbinghaus Test 2 Question: What is the time constant of short term memory? FER GUJ MAW QON NID WAP GOC DOM JIS ZUN

  6. M-Z: Write Delay=0 minutes and write down word list A-L: Write Delay=1 minute and write down word list after waiting one minute

  7. Score memory test FER GUJ MAW QON NID WAP GOC DOM JIS ZUN

  8. Classical Conditioning Ivan Pavlov

  9. Pavlovian Associative Conditioning Conditioned Stimulus Unconditioned Stimulus Unconditioned Response Conditioned Stimulus Conditioned Response

  10. Delay Conditioning US CS Time Trace Conditioning US CS Time Categories of Associative Conditioning

  11. Eye-Blink Conditioning in Rabbits Corneal Air Puff Given with Tone Tone Given Alone Elicits Eyeblink Response Corneal Air Puff Elicits Eyeblink Response

  12. TRAINING • Animal is placed in novel context • Hears a tone • Receives foot shock CONTEXTUAL TEST CUED TEST • Animal is returned to same context • Test for freezing behavior • Animal is placed in modified context • Hears a tone • Test for freezing behavior Fear Conditioning

  13. Cued-Plus-Contextual Fear Conditioning Cued Training Contextual

  14. Conditioned Taste Aversion A B DAY 1 1.0 1st Exposure to Food Item 0.8 0.6 grams blueberry bar 0.4 Injection of LiCl or NaCl 0.2 0.0 DAY 2 LiCl NaCl Grams Ingested on 2nd Exposure (LiCl treated group compared to NaCl treated control) 2nd Exposure to Food Item

  15. Neophobia 0.8 1st Exposure to Food Item 0.6 grams blueberry bar 0.4 0.2 0.0 1st intake 2nd intake 2nd Exposure to Food Item A B DAY 1 DAY 2 Grams Ingested (1st exposure compared to second exposure)

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