pharmacology b
Download
Skip this Video
Download Presentation
Pharmacology B

Loading in 2 Seconds...

play fullscreen
1 / 14

Pharmacology B - PowerPoint PPT Presentation


  • 64 Views
  • Uploaded on

Pharmacology B. Lin, I-Yao. A 43y/o male CEO of a multinational company experienced severe burning pain one and a half hour after a sumptuous lunch. This is accompanied by mild nausea and vomiting. He was given a glass of milk and some cookies which apparently provided some relief.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Pharmacology B' - fairly


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
pharmacology b

Pharmacology B

Lin, I-Yao

slide2
A 43y/o male CEO of a multinational company experienced severe burning pain one and a half hour after a sumptuous lunch. This is accompanied by mild nausea and vomiting. He was given a glass of milk and some cookies which apparently provided some relief.
diagnosis peptic ulcer of duodenum
Diagnosis: Peptic ulcer of duodenum
  • Ulcer of the distal stomach and proximal duodenum caused by gastric secretions (hydrochloric acid and pepsin) and impaired mucosal defenses.
  • It’s associate with Helicobacter pylori which increased hydrochloric acid secretion, and inadequate mucosal defense against gastric acid.
slide4
Cause:
  • Using aspirin medicine
  • Drinking alcohol excessively
  • Smoking cigarettes and using tobacco
  • Others.

Sign and symptoms:

  • Nausea and vomiting.
  • Weight loss
  • Fatigue
  • Heartburn, indigestion, belching.
  • Vomiting blood
  • Bloody or dark tarry stools
lab examination
Lab examination:
  • Gesophagogastroduodenoscopy (EGD) .
  • Take biopsy to test for H, pylori.
  • Stool guaiac to test for blood in the stool.
  • Schilling test to check for anemia.
treatment approaches include
Treatment approaches include:
  • Eradicating the H. pylori infection.
  • Reducing secretion of gastric acid or neutralizing the acid after it is released.
  • Providing agents that protect the gastric mucosa from damage.
treatment medication
Treatment - medication

NaHCO3, Mg(OH)2, Al(OH)3.

Proton-Pump inhibitors: Omprazole, Lansoprazole.

H2 – Antagonists: Cimetidine, Ranitidine.

Sucralfate, Bismuth chelate, Prostaglandins

Omprazole + Clarithromycin + Amoxillin/ Metronidazole

slide9

-weak base that react with gastric HCl to form salt and water

-reduce gastric acidity

-reduce pepsin activity

Side effect:

NaHCO3-systemic alkalosis

Mg(OH)2-diarrhea, hyper magmesemia

Al(OH)3-constipation, hypophosphatemia

slide10

1. Proton-Pump inhibitors: Omprazole, Lansoprazole.

-inhibits gastric parietal cell proton pump H+/K+ ATPase, dercease gastric acid secretion.

2. H2 – Antagonists:

-blocker H2-receptor and reduce cAMP which inhibit gastric acid secretion.

Side effect:

Cimetidine-confusion, reversible gynecomastia.

Ranitidine-headache.

The H2-receptor antagonist can’t combined with PPI inhibitor which the H2-receptor antagonist even inhibit omeprazole.

slide11
  • Sucralfate

-selective binding to necrotic ulcer tissre and act as barrier to acid, pepsin, bile.

-requires acid pH to be activated, there fore should not be used with antacid, H2 antagonist or proton pump inhibitors.

2. Bismuth chelate

-binds and ulcer tissue, coat it and protectit from acid and pepsin.

3. Prostaglandins

-inhibits secretion of HCl and stimulates secretion of mucus and bicarbonate (cytoprotective effect).

non pharmacology
Non pharmacology:
  • Avoid food and drink that seems to cause more severe symptoms such as spicy foods, coffee and possibly alcohol.
  • stop smoking.
  • Should be lose excess weight if overweight.
ad