Advancexo's Journey to Superior Exosome Manufacturing

1. Advancexo: Journey to Superior Exosome Manufacturing From Lab to Clinic www.advancexo.com

2. Introduction to Exosomes in Dermatology The field of dermatology is always evolving, seeking new and innovative therapies for skin and hair care. One such groundbreaking development is exosomes. Exosomes are tiny biovesicles essential for cell-to-cell communication. These exosomes extracted from mesenchymal stem cells are rich in rejuvenating factors. 02 www.advancexo.com

3. The Journey of Exosomes The Journey Of Bringing Exosomes From The Laboratory To Clinical Application Is Filled With Challenges. • Challenges includes: • Sterility of stem cells and exosomes • The number of exosomes packed in a vial • Size of exosomes • Quality of the source of the exosomes • Prevent differnetiation of stem cells Advancexo has positioned itself as a leader in exosomes manufacturing, by ensuring that we deliver top-quality exosome products to dermatologists. 03 www.advancexo.com

4. What Sets Advancexo Apart? • In-house GMP compliant laboratory to process stem cells and isolate exosomes • Commitment to superior exosome manufacturing process • Rigorous and meticulous Quality standards Advancexo exosomes meet the highest industry standards, providing dermatologists with superior products 04 www.advancexo.com

5. Step 1: Donor Selection • We use umbilical cord mesenchymal stem cells • Carefully select donors by evaluating their medical history • Ensure there are no genetic disorders • Obtain the consent before the delivery 06 www.advancexo.com

6. Step 2: Processing and Expanding the Stem Cells • Umbilical cord is processed in GMP-compliant laboratories. • Check the stem cells for infectious diseases • Ensure the cells are free from contamination with regular checks • The stem cells are expanded carefully, maintaining their stemness • Do multiple screenings for contamination and genetic abnormalities 07 www.advancexo.com

7. Step 3: Extraction of Exosomes • Collect the media in which stem cells were growing • Remove cell debris • Use tangential flow filtration technology to filter the exosomes based on their size • Ensuring the highest yield and purity • Process the exosomes for sterility using chemicals and filtration step https://cdn-kagjh.nitrocdn.com/YYqyIUzIVqFJVddbQVkNJItDOXjvQJpp/assets/images/optimized/rev-15a5c81/www.pharm-int.com/wp-content/uploads/2023/01/Lyophilization-how-the-process-works.png 07 www.advancexo.com

8. Step 4: Storage & Shipping of Exosomes • Different exosome manufacturing companies have various methods, such as freeze-drying or spray drying. • Advancexo lyophilize the exosomes to ensure long-term stability. • Lyophilized exosomes are provided along with bioactivating solution, making them ready for clinical use. https://www.researchgate.net/figure/Tangential-flow-filtration-ensures-highly-efficient-ultrafiltration-During-tangential_fig4_339544937 07 www.advancexo.com

9. Conclusion • Advancexo is the leading exosomes manufacturing company in Idia supplying high-quality exosomes designed to meet the evolving needs of dermatology. • Our commitment to innovation, rigorous quality standards, and superior manufacturing processes is paramount for us. • Dermatologists are leverage the power of exosomes to revolutionize their clientele lives 07 www.advancexo.com

10. Contact us: Website www.advancexo.com Phone +91-9654321400 Email Address info@advancells.com Address 1st Floor, A-102, Block A, Sector 5, Noida, Uttar Pradesh - 201301 www.advancexo.com