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Ross Lab - Biophysics

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  1. Ross Lab - Biophysics 10 m Cytoskeleton: Rich Biological System of Interest • Microtubules Shape the Cell • Motor Proteins Move Objects and Microtubules • Microtubule regulation through modifications and motor proteins • Microtubule Motors Traffic Problems Dynein, Kinesin, Eg5, MAPs Using Total Internal Reflection Fluorescence (TIRF) Microscopy Optical trapping of motors to measure force • Microtubule Severing Enzymes Katanin, Spastin, Fidgetin Using TIRF microscopy March of Dimes Funded • Microtubule Mechanics Stability, Flexibility, Structural Studies NSF funded Green = Microtubules Blue = DNA Ross, et. al., Biophysical Journal 2008 Website: www.people.umass.edu/rossj Email: rossj@physics.umass.edu

  2. Ross Lab - Biophysics • Biochemistry and Molecular Biology: Protein Design, Purification, and Characterization • Microscopy: Epi-fluorescence, TIRF, electron microscopy, AFM • Analysis: Image analysis, MATLAB analysis, measure velocity, intensity, Fourier modes BioBootCamp 2010