tsc2 and tuberous sclerosis complex disease n.
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TSC2 and Tuberous Sclerosis Complex Disease. Laura Koontz Biology 169. www.xray2000.f9.co.uk/ibase3/rain/album20.html. TSC2. TSC2 encodes the protein tuberin Tuberin was found to be a G TPase A ctivating P rotein (GAP) specific to Rheb, a Ras-like protein

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tsc2 and tuberous sclerosis complex disease
TSC2 and Tuberous Sclerosis Complex Disease

Laura Koontz

Biology 169

www.xray2000.f9.co.uk/ibase3/rain/album20.html

slide2
TSC2
  • TSC2 encodes the protein tuberin
  • Tuberin was found to be a GTPase Activating Protein (GAP) specific to Rheb, a Ras-like protein
  • Mutations in TSC2 cause inappropriate activation of Rheb and downstream effectors
tsc2 tuberin blocks rheb signaling in the absence of ligand
TSC2(Tuberin) blocks Rheb signaling in the absence of ligand

Manning, B.D., et. al. Rheb fills a GAP between TSC and TOR. 2003. Trends in Biochemical Science. 28: 573 – 576.

in the presence of growth factor tsc2 tuberin is inhibited
In the presence of growth factor, TSC2 (Tuberin) is inhibited

Downstream effectors that turn on protein synthesis

Manning, B.D., et. al. Rheb fills a GAP between TSC and TOR. 2003. Trends in Biochemical Science. 28: 573 – 576.

tsc2 functions to regulate cell growth
TSC2 functions to regulate cell growth

Tapon, N., et. al. 2001. The Drosophila Tuberous Sclerosis Complex Gene Homologs Restrict Cell Growth and Cell Proliferation. Cell 10:345 – 355.

slide7

TSC2+/- mice develop bilateral tumors; a good model for human TS

Arrows indicate bilateral renal tumors developing concurrently (from a 7 month old female mouse)

Kobayashi, T., et. al. 1999. Renal Carcinogenesis, Hepatic Hemangiomatosis, and Embryonic Lethality Caused by a Germ-Line TSC2 Mutation in Mice. Cancer Research 59: 1206 – 1211.

tsc2 is a tumor suppressor
TSC2 is a tumor suppressor

TSC2 down-regulates the production of protein synthesis machinery in the absence of ligand.

TSC2-/- mutant cells have an increased cell size, but do not divide.

Mutations in TSC2 are inherited in an autosomally dominant manner, comparable to RB inheritance.

slide9

How is TSC2 related to cancer?

  • Tuberous sclerosis derives its name from the tuber-like growths associated with it.
  • These growths, called hamartomas, are benign tumors that can effect many different organs in the body:
  • Skin
  • Heart
  • Lungs
  • Brain
  • Kidneys

www.xray2000.f9.co.uk/ibase3/rain/album20.html

http://myweb.lsbu.ac.uk/~dirt/museum/unk-chest.html

www.schoolscience.co.uk/content/5/biology/mrc/15/page4.html