electrical impedance tomography with tomosynthesis for breast cancer detection jonathan newell n.
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Electrical Impedance Tomography with Tomosynthesis for Breast Cancer Detection Jonathan Newell. With: David Isaacson Gary J. Saulnier Tzu-Jen Kao Greg Boverman Richard Moore* Daniel Kopans*

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electrical impedance tomography with tomosynthesis for breast cancer detection jonathan newell

Electrical Impedance Tomography with Tomosynthesis for Breast Cancer DetectionJonathan Newell

With:

David Isaacson Gary J. Saulnier

Tzu-Jen Kao Greg Boverman

Richard Moore* Daniel Kopans*

And: Rujuta Kulkarni Chandana Tamma

David Ardrey Neha Pol

RensselaerPolytechnicInstitute

*Massachusetts General Hospital

eit electrodes added to mammography machine
EIT electrodes added to mammography machine.
  • 1 : 2 : 4 : 2 : 1 is the ratio of the mesh thicknesses.
  • Only the center layer, III, is displayed in the results.
eit instrumentation
EIT Instrumentation

ACT 4 with Tomosynthesis unit

Radiolucent electrode array

co registration of eit and tomo images
Co-registration of EIT and Tomo Images

To find the electrode position, display the slice containing the electrodes.

Superimpose the mesh grid with correct scale.

Slice 15 of 91

HS_14R

Normal

Then select the desired tomosynthesis layer.

Slice 50 of 91

admittance loci format for summaries of eis data
Admittance Loci: format for summaries of EIS data

Results of in-vitro studies of excised breast tissue.Jossinet & Schmitt 1999

linear correlation measure lcm

LCM Image

700

Y

Ym

0

compute for

each voxel

Linear Correlation Measure –LCM
lcm image of fibroadenoma hs21 r
LCM Image of fibroadenoma (HS21_R)

350

0

Gray scale image of LCM

lcm image of invasive ductal ca hs10 l
LCM Image of invasive ductal CA (HS10_L)

1300

0

Gray scale image of LCM

lcm for 11 normal breasts
LCM for 11 normal breasts

300

0

There are 120 EIS plots for layer 3 in each patient. The distribution of the LCM parameter in these plots is shown.

lcm for the regions of interest in 4 patients
LCM for the regions of interest in 4 patients

Hyalinized

Fibroadenoma

Invasive ductal

carcinoma

Normal

Normal

The distributions of the LCM for the regions of interest identified. Note the LCM values are much larger for voxels associated with the malignant lesions.

lcm on the same scale for a normal subject a fibroadenoma and two carcinomas
LCM on the same scale for a normal subject, a fibroadenoma and two carcinomas

Normal Breast

Fibroadenoma

Invasive Ductal

Carcinoma

Invasive Ductal

Carcinoma

conclusions
Conclusions
  • We have discovered a quantitative parameter derived from the admittance spectra that is markedly different in malignancy from normal breast tissues.
  • This parameter is location-specific to the tumor.
  • We need to study more patients with more benign lesions and tumors in order to evaluate the clinical potential of this parameter to improve the sensitivity and specificity of breast cancer screening.
  • We will present additional details about our system and its results in four posters at this meeting. See Kao, Boverman, Kulkarni and Tamma.
summary of first 38 patients accrued
Summary of first 38 patients accrued
  • Total patient studied: 37-7 = 30
  • First 7 patients were needed to develop correct operational procedures.
  • 19 breasts are underwent biopsy
  • 7 of these were reported as CA
  • 4 breasts of these were located outside of the electrode region.
  • 3 CA breasts are OK for analysis
threshold for parameter straightness image
Threshold for Parameter, Straightness image
  • After preliminary study, we can set a threshold for normal or abnormal EIS plot.
  • 400 will be the first guess with these patient data.
  • The previous image will be show again with full scale set to 700.