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Case 21

Diagnostic Challenge Pathology for Neurosurgery & Neurology Residents Department of Pathology University of Oklahoma Health Sciences Center, Oklahoma City, OK, U.S.A. Case 21

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Case 21

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  1. Diagnostic ChallengePathology for Neurosurgery & Neurology ResidentsDepartment of PathologyUniversity of Oklahoma Health Sciences Center,Oklahoma City, OK, U.S.A. Case 21 History: A 68 year-old man was admitted for confusion and decreased mental status. He died later and an autopsy was performed. Author: Kar-Ming Fung, M.D., Ph.D., karming-fung@ouhsc.edu Last updtaded: 5/5/2008

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  4. Acid Fast Stain

  5. What is your diagnosis?

  6. Diagnosis: Tuberculous meningitis. • Discussion: • The leptomeninges is thickened and have increased cellularity (white arrow) in the spinal cord. Many small nodules are there (black arrow) and these are granulomas. The center of the granulomas have caseous necrotic center (n). • On acid fast stain, positive bacilli are cultured out (red arrow). n

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