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Immune Escape Mechanisms in Leishmaniasis

Immune Escape Mechanisms in Leishmaniasis. Nancy Noben-Trauth, Ph.D. Assistant Professor Department of Microbiology, Immunology & Tropical Medicine The George Washington University Medical Center nnoben@gwu.edu , 994-0531. Visceral Leishmaniasis. Cutaneous Leishmaniasis. Self-healing ulcer.

emmanuel-manning
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Immune Escape Mechanisms in Leishmaniasis

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  1. Immune Escape Mechanisms in Leishmaniasis Nancy Noben-Trauth, Ph.D. Assistant Professor Department of Microbiology, Immunology & Tropical Medicine The George Washington University Medical Center nnoben@gwu.edu, 994-0531

  2. Visceral Leishmaniasis Cutaneous Leishmaniasis Self-healing ulcer “Leishmanization” with live leishmania

  3. Th2=BAD (Infection) Th1=GOOD (Cure) Th2 Th1 IL-4 IL-13 IFN Th2 Th1 Allergy Infections Autoimmunity Inflammation Susceptible Resistant IL-4 IL-13 IL-10 IFNg TNFa IL-2 The Th1/Th2 Paradigm in Immunology Leishmania

  4. Th2 Th1 Susceptible Resistant IL-4 IL-13 IL-10 IFNg TNFa IL-2 The NEW Paradigm in Leishmania IL-4R KO mice are defective in Th2 responses, but remain susceptible to Leishmania major infection IL-10 Th2 A New Immune Escape Mechanism

  5. Th2 Th1 Susceptible Resistant IL-4 IL-13 IL-10 IFNg TNFa IL-2 Possible GWU Collaborations IL-4R KO mice to study Models of Inflammation IL-10 gene analysis Th2 Macrophages from IL-4R KO mice produce IL-10

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