Child Psychiatry Research Methods Lecture Series. Lecture 8: Issues in MRI and fMRI Analyses . Elizabeth Garrett firstname.lastname@example.org. Analysis of Imaging data. New, exciting area of research: growth (partly) due to increases in computer technology for handling data. ENORMOUS amount of data
Two types of “analysis” that we hear about in MRI and fMRI studies:
(1) analysis that converts the readings from the MRI to “data”. This process is time intensive and takes a trained expert. There are multiple outputs from this process, including 3D pictures, volumes, intensities, etc.
(2) analysis that uses the “data” from part (1) in a statistical way to answer scientific questions.
We will discuss ONLY (2).
(1) is a whole other can of worms.
pvalue = 0.033
Figure 1. fMRI of picture naming in a normal control, p<0.01, demonstrating prominent left temporal, left posterior frontal and right peri-Rolandic activation, overlaid on T1 images. TR/TE = 1sec/50msec, flip angle 70, 7 mm slices, image matrix 64x64.
Example of “lighting up”
At EACH voxel, plot intensity versus time:
Perform a regression to see if activation is different when light is on versus off:
Consider intensity of activation
p < 0.001
Clinical Research Methods
Science of Clinical Investigation