World Health Day 2011

1. World Health Day 2011 Combating Drug Resistance Syed Khalid Saeed Bukhari

2. World Health Day 2011 • The Regional theme is combating Drug Resistance (DR) • The slogan is "COMBAT DRUG RESISTANCE, NO action today, NO cure tomorrow"

3. Pakistan • 30% prescription lack a diagnosis/complaint. • EDL was present in 19% health facilities. • 1 in 6 prescription do not contain any dosage instructions. • According to EDSP 2002 report prescription contain 52% antibiotics.

4. Percentage of Encounters with antibiotic

6. No  action today, no cure tomorrow • DR kills human lives • Challenges care and control of infectious diseases • Greatly increases care costs • Threatens healthcare gains for individuals and society • Can take us back to the pre-antibiotic era • Threatens health security and damages trade and economy

8. DECLINE OF RESPIRATORY TUBERCULOSIS Low relative impact of health care in other diseases See the trend in decline of the disease was there even before the advent of modern medicine Modern medicine contributed only a portion of further decline The main decline was due to improved hygiene, sanitation, living conditions, lifestyles, preventive approaches, and these are all important public health practices we teach and advice DECLINE IN CHILDHOOD DIPTHERIA DECLINE IN CHILDHOOD MEASLES Thomas McKeown The role of Medicine: Dream, Mirage, or Nemesis. 1980

9. WHD 2011: What will we achieve? Goal: To save lives and protect health by keeping precious, life-saving medicines effective and useful to combat diseases Aims:- To raise awareness on what drives DR- To build commitment for effective policies and practices and their implementation to combat DR Objectives: • To provide policy guidance to Member States on top priority actions to combat DR • To reach and engage key stakeholders through innovative communications, advocacy and events • To promote further collaboration across sectors and among stakeholders

10. What is DR? • DR arises when • Patients do not take their medicine properly and rationally • Providers do not prescribe the medicine properly • Patients and community do not know proper use of medicine & problem of drug resistance • Health authorities do not maintain quality of drugs • Hospitals do not adopt infection control measures • Health policy makers do not prioritize drug resistance containment • There is limited research on new medicine

11. What is DR?......... • TB: 440,000 new multidrug resistance (MDR) TB cases annually; extensively drug resistance (XDR) TB cases reported in 58 countries so far • Malaria: Emergence of Artemisin resistance linked to ongoing use of monotherapies • HIV: With expanded use of antiretrovirals (ARVs), resistance is a concern

12. What is DR……. • Methicillin-resistant Staphylococcus aureus: lethal infections in hospital settings which are becoming increasingly frequent • Multi-drug resistant E. coli and K. pneumoniae: infections are on the rise • Neisseria gonorrheaeand Shigella: are becoming increasingly resistant to drugs

13. What drives DR? • Policy • Drug resistance plans & resources are not comprehensive • Monitoring • Surveillance system is weak • Quality assurance • System to ensure quality and supply of medicine is inadequate

14. What drives DR? • Awareness • Consumers and communities are not aware of drug resistance • Prevention • Poor Infection prevention & control • R&D • Research & development for diagnostics and drugs is insufficient

15. Six Steps to Stop DR • Political commitment Committing to a comprehensive, financed national plan with lines of accountability and civil society engagement • Monitoring Strengthening surveillance and laboratory capacity • Quality control & assurance Ensuring medicines of good quality and regular supply • Rational use of medicine Regulating and promoting rational use of medicines, including in agricultural sector, and proper patient care • Prevention & stopping the spread Enhancing infection prevention & control • R&D Fostering innovations, research & development

16. To address DR, we should know: • DR is complex as • it involves different diseases, settings • and demands well coordinated actions across different sectors • DR is also a behavioral issue • DR is EVERY BODY’ problem

17. WHO Global strategy • In September 2001, WHO launched the first Global Strategy for Containment of Antimicrobial Resistance which aims to encourage the urgent actions needed to reverse or at least curtail trends which have major economic as well as health implications.

18. WHO Policy & strategy options Addressing antimicrobial resistance requires a comprehensive multisectoral approach • Target audience” Intervention area • Government (health systems) • Patients and the general community • Pharmacists • Prescribers and dispensers • Hospitals • Pharmaceutical industry • Food production

19. Advocacy and intersectoral action • Intersectoral task force • Resources to promote the implementation of interventions • Indicators to monitor and evaluate the impact of resistance • Regulations • Prescription-only status • International quality, safety and efficacy standards

20. Policies and guidelines • National Drug Policy and Essential Drugs List (EDL) • Surveillance • Designate or develop reference microbiology laboratory facilities • Drug resistance surveillance

21. Health education • Appropriate use of antimicrobials • Disease prevention (immunization, vector control) • Hygiene • Education (undergraduate an postgraduate) • Appropriate use and containment • Disease prevention and infection control • Diagnosis and management • Management, guidelines and formularies • Prescription audits / prescription limits • Standard treatment guidelines and prescription limits • Regulation • Professional registration based on continuing education

22. Promotional activities • Control and monitor promotion for medicines(WHO ethical criteria) • Quality • Good Manufacturing Practice (GMP) of pharmaceuticals and diagnostics

23. National intersectoral task force on antimicrobial resistance • Legislation and regulation:prescription-only use of antimicrobials • Hospital therapeutics committees and infection control programmes • Essential drugs concept in educational programmes

24. WHO's response • policy guidance, support for surveillance, technical assistance, knowledge generation and partnerships, including through disease prevention and control programmes; • essential medicines quality, supply and rational use; • infection prevention and control; • patient safety; • laboratory quality assurance

25. Messages on DR • Policy makers Ministries of Health, other than Ministry health policy influencers & makers: • The threat of DR is real & enormous; • needs vigorous response with allocation of proper resources, public awareness campaigns, • and the establishment and enforcing of clear policies to prevent the onset and dissemination of DR

26. Messages on DR • The public: • understand and adopt the appropriate use of, or alternatives to, antimicrobials • prevent from and get treatment for infectious diseases; and • learn & adopt measures to reduce transmission

27. Messages on DR • Practitioners & prescribers • understand and appropriately use antimicrobials against TB, malaria and HIV and other diseases • learn and adopt disease prevention and infection control measures

28. Messages on DR • Media: • promote awareness of DR as a real, enormous public health threat • encourage actions at policy levels to address DR

29. Messages on DR • Pharmaceutical industry • promote production of quality drugs • foster proper branding, publicity, and marketing measures that favor prevention and containment of DR

30. THANK YOU