leprosy hansen s disease l.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
Leprosy (Hansen’s Disease) PowerPoint Presentation
Download Presentation
Leprosy (Hansen’s Disease)

Loading in 2 Seconds...

play fullscreen
1 / 22

Leprosy (Hansen’s Disease) - PowerPoint PPT Presentation


  • 175 Views
  • Uploaded on

Leprosy (Hansen’s Disease). Amanda Lee BIOL 402. Leprosy is caused by Mycobacterium leprae . Scollard, DM et al. 2006. “The continuing challenges of leprosy.” Clinical microbiology reviews 19, no. 2: 338-81. . Discovered by Gerhard Armauer Hansen in 1873.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Leprosy (Hansen’s Disease)' - ely


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
leprosy is caused by mycobacterium leprae
Leprosy is caused by Mycobacterium leprae

Scollard, DM et al. 2006. “The continuing challenges of leprosy.”

Clinical microbiology reviews 19, no. 2: 338-81.

discovered by gerhard armauer hansen in 1873
Discovered by Gerhard Armauer Hansen in 1873

Global Project on the History of Leprosy

http://www.leprosyhistory.org/graphics/gallery/hansen.jpg

bacteria resides in cooler parts of the body
Bacteria Resides in Cooler Parts of the Body

Peripheral Nerves

Skin

http://www.nlm.nih.gov

symptoms diagnosis 1 skin lesions
Symptoms & Diagnosis: (1) Skin Lesions

Worobec, Sophie M. 2009. “Treatment of leprosy/Hansen's disease in the early 21st century.” Dermatologic therapy 22, no. 6: 518-37.

symptoms diagnosis 2 skin smear tests
Symptoms & Diagnosis: (2) Skin Smear Tests

Ziehl Neelsen Carbol Fuchsin Stain (ZNCF)

Global Project on the History of Leprosy

http://www.leprosyhistory.org/graphics/gallery/mleprae.jpg

transmission
Transmission
  • Nasal/oral Droplets
  • Dermal Inoculations
mechanism of nerve damage
Mechanism of Nerve Damage
  • Entry Through Blood Vessels

2. Inflammatory Response

3. Demyelination

Scollard, DM et al. 2006. “The continuing challenges of leprosy.”

Clinical microbiology reviews 19, no. 2: 338-81.

slide10

Outcomes of Nerve Damage

  • Sensory Loss
  • Paralysis
  • Deformities

Leprosy: eMedicine Infectious Diseases

http://emedicine.medscape.com/article/220455-overview

sensory loss can lead to secondary infections and severe deformities
Sensory Loss Can Lead to Secondary Infections and Severe Deformities

International Federation of Anti-Leprosy Associations (ILEP)

http://www.ilep.org.uk/en/

1941 discovery of dapsone
1941: Discovery of Dapsone
  • Targets dihydropteroate synthase (DHPS)
  • Inhibits nucleic acid synthesis
1964 dapsone resistance from missense mutations in dhps
1964: Dapsone Resistance from Missense Mutations in DHPS

Matsuoka, Masanori M. 2010. “Drug Resistance in Leprosy.” Japanese journal of infectious diseases 63, no. 1: 1-7.

1960 s rifampicin and clofazimine discovered
1960’s: Rifampicin and Clofazimine Discovered
  • Rifampicin (Rifampin): Inhibit RNA synthesis
  • Clofazimine:

Anti-inflammatory

1981 who proposes multi drug therapy mdt
1981: WHO Proposes Multi-Drug Therapy (MDT)
  • Combination of DAPSONE, RIFAMPICIN, and CLOFAZIMINE

+

+

slide16

The Nippon Foundation

http://www.nippon-foundation.or.jp/eng/

obstacles to eliminating leprosy in endemic countries
Obstacles to Eliminating Leprosy in Endemic Countries

STIGMA

World Health Organization. 2001. “Leprosy: Learning from Success.”

WHO Publications on Leprosy.

overcoming stigma
Overcoming Stigma
  • Mass Media
  • Integrated Primary Health Services
  • Education & Training
slide21

Worobec, Sophie M. 2009. “Treatment of leprosy/Hansen's disease in the early 21st century.”

Dermatologic therapy 22, no. 6: 518-37.

references
References
  • Leprosy Today. “Leprosy: The Disease.” World Health Organization. http://www.who.int/lep/leprosy/en/index.html (accessed February 25 2010).
  • Matsuoka, Masanori M. 2010. “Drug Resistance in Leprosy.” Japanese journal of infectious diseases 63, no. 1: 1-7. http://www.nih.go.jp.libproxy.lib.unc.edu (accessed February 25, 2010).
  • National Hansen’s Disease (Leprosy) Program. “Hansen’s Disease (Leprosy) Facts.” U.S. Department of Health and Human Services. http://www.hrsa.gov/hansens/ Accessed February 25 2010.
  • Scollard, DM, LB Adams, TP Gillis, JL Krahenbuhl , RW Truman, and DL Williams. 2006. “The continuing challenges of leprosy.” Clinical microbiology reviews 19, no. 2: 338-81. http://www.ncbi.nlm.nih.gov.libproxy.lib.unc.edu (accessed February 25, 2010).
  • Worobec, Sophie M. 2009. “Treatment of leprosy/Hansen's disease in the early 21st century.” Dermatologic therapy 22, no. 6: 518-37.http://www3.interscience.wiley.com.libproxy.lib.unc.edu(accessed February 25, 2010.