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Usage of WATERMODULE A routine for estimating myocardial blood flow based on Iida model developed for MunichHeart. Chunlei Han Turku PET center Turku, Finland November, 2002 chunlei.han@tyks.fi. INPUTPUT. Time: one-dimension array with n-element

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slide1

Usage of WATERMODULE

A routine for estimating myocardial blood flow based on Iida model

developed for MunichHeart

Chunlei Han

Turku PET center

Turku, Finland

November, 2002

chunlei.han@tyks.fi

slide2

INPUTPUT

Time: one-dimension array with n-element

LV: one-dimension array with n-element

allTACs: two-dimension array (m*n)

StudyType: string, “rest” or “stress”, to indicate study type

method: calculation method, ‘regress’,’svdc’, ‘constrained_min’

‘powell’, ‘pfdmin’ and ‘curvefit’. Default is ‘constrained_min’

cProtocol: string, “FreeAlfa” or “FixAlfa”, to indicate calculation

with or without fixing alfa, default is “FreeAlfa”

alfa_Rest_whole: scalar, rest study alfa value for average ROIs.

alfa_Rest_regional: one-dimension array with n-element

slide3

Input argument structure

Time

0.2

0.3

..

5.00

LV

1.2

10.3

334.4

...

...

30.0

allROIs

ROI1 ROI2 …… ROIm

0.34 …… …….

20.5

490.5

...

...

25.5 …… ……

Alfa_Rest_regional

0.2

0.3

0.5

...

0.4

Alfa_Rest_whole=0.33

slide4

OUTPUT

Output is a structure with fields of

whole_Va: Va for average ROIs

whole_f: f for average ROIs

whole_alfa: alfa for average ROIs

cInputfunction: calculated aterial input function

regional.Va: Va for all ROIs

regional.f: f for all ROIs

regional.alfa: alfa for all ROIs

regional.fittedcurve: fitted curves for all ROIs

regional.fitquality: number 0-7 to indicate of fit goodness, only meaningful

in “constrained_min”

slide5

Call Sequence

General

WATERMODULE(time, LV, allTACs, StudyType, method,

cProtocol, alfa_Rest_whole, alfa_Rest_regional)

Rest study

WATERMODULE(time, LV, allTACs, StudyType method,)

where StudyType=‘rest’

Stress study with free alfa

WATERMODULE(time, LV, allTACs, StudyType, method, cProtocol)

where StudyType=‘stress’ and cProtocol=‘FreeAlfa’

Stress study with fixed alfa

WATERMODULE(time, LV, allTACs, StudyType, method, cProtocol, alfa_Rest_whole, alfa_Rest_regional)

where StudyType=‘stress’ and cProtocol=‘FixAlfa’, also for alfa values from rest study

slide6

Default values and common block

Default values

default_p=0.91

default_beta=0.93

default_A=[0.5,1.0,0.5]

default_xbnd=[[0,0,0],[1,50,1]]

default_tolerance=1.0e-4

default_method=‘constrained_min’

default_Miter_constr=1000

default_Miter_curvefit=20

default_Miter_powell=200

Common block

COMMON Xpara, Xin,Yin, FixAlfa_whole,FixAlfa_regional, constant

constant={p:0.0,beta:0.0,xbnd_default:fltarr(3,2),A_initial:fltarr(3,1)

tolerance:0.0,Miter_constr:0.0,Miter_curvefit:0.0,Miter_powell:0.0}

slide7

Function Call Flow

watermodule

Iida_whole

Iida_regional

StudyType=‘rest’ or

StudyType=‘stress’ and cProtocol=‘FreeAlfa’

StudyType=‘stress’ and

cProtocol=‘FixAlfa’

Func_whole_FixAlfa

Func_whole_FixAlfa_curvefit

Func_whole_FixAlfa_dfpminGRAD

Func_whole_FreeAlfa

Func_whole_FreeAlfa_curvefit

Func_whole_FreeAlfa_dfpminGRAD

Func_regional_FreeAlfa

Func_regional_FreeAlfa_curvefit

Func_regional_FreeAlfa_dfpminGRAD

Func_regional_FixAlfa

Func_regional_FixAlfa_curvefit

Func_regional_FixAlfa_dfpminGRAD