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R E MUS: a tool for identification of unique peptide segments as epitopes

R E MUS: a tool for identification of unique peptide segments as epitopes. Dr. Tun-Wen Pai Dept. of Computer Science and Engineering, National Taiwan Ocean University 2006/10/30.

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R E MUS: a tool for identification of unique peptide segments as epitopes

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  1. REMUS: a tool for identification of unique peptide segments as epitopes Dr. Tun-Wen Pai Dept. of Computer Science and Engineering, National Taiwan Ocean University 2006/10/30

  2. REMUS : A web server for identification of the locations and compositions of unique peptide segments from a set of protein family sequences ( http://140.121.196.30/remus) • DNA / PROTEIN levels • Web interface / PC version for Windows • Refs: 1. H. Chang, T. Pai, D. Chang, et al., A Reinforced Merging Methodology for Mapping Unique Peptide Motifs in Members of Protein Families”, BMC Bioinformatics 7:38 (SCI), 2006. 2. T. Pai, M. Chang, W. Tzou, et al., “REMUS: a tool for identification of nique peptide segments as epitopes”, Nucl. Acids Res. Web Server Issue(in press) (SCI) , 2006.

  3. Searching phase Grouping phase Merging phase System Architechure

  4. System features: • Bottom-up approximate searching technology • Statistical properties analysis for each primary segment (Uniqueness Representation) • Automatic / Semi-Automatic version (Automatic Primary Pattern Analysis) • Substitutable Residues (BLOSUM/PAM) • Various Merging Methods • Chemical Properties (Ranking Order) • Structural Representation (loop structure analysis)

  5. Example (Web Version):

  6. Example (Results of REMUS):

  7. Example (3D representation):

  8. Example (UPM representation):

  9. Example (Various Styles):

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