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Drug Resistance Monitoring . in Cambodia 1997 - 2003. Sensitivity (S or S/RI) at 4 sentinel sites 1991 – 97. Western areas: Battambang, Pursat, Eastern areas: Ratanakiri, Kratie Chloroquine - 1991-93 (West): S or S/RI = 3-12% -1997 (East): S/RI = 76%-86% Fansidar®

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Drug resistance monitoring l.jpg

Drug Resistance Monitoring

in Cambodia 1997 - 2003


Sensitivity s or s ri at 4 sentinel sites 1991 97 l.jpg

Sensitivity (S or S/RI) at 4 sentinel sites 1991 – 97

Western areas: Battambang, Pursat,

Eastern areas: Ratanakiri, Kratie

Chloroquine

-1991-93 (West): S or S/RI = 3-12%

-1997 (East): S/RI = 76%-86%

Fansidar®

-1991-95 (West): S or S/RI = 0-13%

-1991-95 (East): S or S/RI = 57-80%

Quinine and Tetracycline

-1994-95 (All areas):S/RI = 100 %

Mefloquine monotherapy:

-1991-97 (West): S or S/RI = 80%-97%

-1992-97 (East): S or S/RI = 100%


Drug resistance monitoring in cambodia 1998 l.jpg
Drug Resistance Monitoring in Cambodia 1998

  • No study

  • Lack of budget

  • Lack of human

    resources

    due to Dengue

    epidemic outbreak


Drug resistance of chloroquine mefloquine monotherapy 1999 l.jpg

Chloroquine

Mefloquine25mg

Sampov Loun

Chloroquine

Rovieng

Mefloquine25mg

Mefloquine25mg/kgw

Mefloquine25mg/kgw

Drug Resistance of Chloroquine & Mefloquine Monotherapy 1999


Drug resistance artecom in cambodia 1999 l.jpg

Sampov Loun

snoul

Drug Resistance Artecomin Cambodia 1999

Artecom(Art.+piperaq.+trimethoprime) 2days,28days follow up


Drug resistance of a m in cambodia 2000 l.jpg

Sampov Loun

Oral,Kg Speu

Drug Resistance of A+M in Cambodia 2000


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Samlot

Snoul

Drug Resistance of A+M Monitoring2001


Drug resistance of artekine 2 coarterm 2001 l.jpg

3

Artekine2

42

Anlong Veng

Artekine2

5

56

15

38

Coarterm

Drug Resistance of Artekine 2 & Coarterm 2001


Drug resistance monitoring a m in cambodia 2002 l.jpg

N=36

N=82

N=75

Drug Resistance Monitoring A+M in Cambodia 2002

Preah Vihear

Ratanakiri

Pailin

Snoul

Veal Veng


Drug resistance of artekine 2 coarterm in cambodia 2002 l.jpg

Sampov Loun

Artekine 2

.

Snoul

N=55

N=65

Coarterm

Drug Resistance of Artekine 2 & Coarterm in Cambodia 2002


Drug resistance monitoring a m in cambodia 2003 l.jpg
Drug Resistance Monitoring A+M in Cambodia 2003

a = PCR confirmed all cases are recrudescing

b = Showed that both are re – infection

c = PCR confirmed all cases are recrudescing

PCR were done by Institute Pasteur of Cambodia


Drug resistance monitoring at sentinel sites cambodia 2002 2003 l.jpg
Drug Resistance Monitoring at sentinel sites, Cambodia 2002 & 2003



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Conclusion

The result showed the sensitivity of A+M still high (ACPR = 92 – 100%) each sentinel site if we compared to the result of previous study.

So The A+M can be continue as drug for our first line treatment of malaria.




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