Ebola Virus. By: Giselle and Matt. Family of Ebola Virus. Filoviridae Comes from the Latin filo meaning “threadlike” Two members Marburg Ebola Virus Five Species Zaire Sudan Reston Ivory Coast Bundibugyo. https://www.imss.org/shop/img/big/ebola.jpg. Filovirus. Very in shape
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By: Giselle and Matt
Comes from the Latin filo meaning “threadlike”
Very in shape
long sometimes branched filaments
Shorter filaments shaped like a “6” or “U” sometimes a circle.
Filaments measure from 80nm (Average) to 14,000nm.
Single-strand negative sense RNA
Five proteins in filoviruses
RNA dependent RNA transcriptase polymerase
Discovered in 1974.
Received it named from the first victims found from the Ebola River Valley in the Democratic Republic of the Congo.
90% mortality rate.
276 out of 300 died.
50% morality rate.
150 out of 285 died.
infected monkeys in the Philippines
The only airborne strain of Ebola virus.
Later found that this strain is not harmful to humans but very devastating to monkeys.
However four people known to have developed antibodies to this strain.
Found in monkey being autopsied by a scientist in 1994.
Scientist became ill from the virus but survived.
Most recently discovered strain of Ebola virus.
Has less power to kill when compared to other strains.
37 out of 150 died.
Some may experience:
Internal and external bleeding
The main cells it will attack are
fibroblastic reticular cells
which form much of the connective tissue.
These cells are under the skin and close by to blood and lymph vessels.
This allows the virus to spread easily in the body.
Ebola will then go on and attack any other connective tissue and epithelial tissue.
This is what causes the hemorrhaging portion of the symptoms.
The virus then moves on to liver and kidney cells.
Ebola once again works similar to HIV in how it evades the immune system.
There is a cellular protein called tetherin
This protein does not save the infected cell.
It prevents the virions from budding off into endosome and escaping.
Ebola disables tetherin like HIV does.
This allows the virus to bud out of the cell.
The virus spreads similar to HIV.
Being evaluated on infected primates.
Vaccine has a recombinant inhibitor factor.
33% survival rate
Although this experimental vaccine shows promising results there are no anti-viral drugs available for clinical use.
The lack of a cure and vaccine makes Ebola a level 4 biohazard.
Level 4 biohazards are kept in special labs known as level 4 biosafety labs.
The first level is for microbial agents that do not cause harm to humans.
The second level is for microbial agents that do cause human disease but transmission is limited.
The third level is for microbial agents that cause severe infections and easily transmitted to humans.
The fourth level is for microbial agents that have no cure or vaccine. They are also highly contagious and pose a significant health threat.
Isolation of the virus for 2-22 days.
There is no treatment for filoviruses.
Treatments of symptoms:
Keeping fluid and electrolyte levels
Maintaining blood pressure and oxygen
Cause of death:
Organ shock or failure associated with fluid and blood loss.
It is still unknown why some infected recover while others die. But those that die have not had a significant immune response before death.
The possibility of a bioterrorist
attack using Ebola is unlikely.
The natural reservoir is
The virus is held in highly
Ebola would make an effective
Weapon because of:
the fear it would instill in
how quickly the virus kills and spreads.