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Exploring Adaptive Immunity: Key Mechanisms and Insights

This comprehensive overview delves into the adaptive immune system, highlighting its two branches: humoral and cell-mediated immunity. It discusses critical interactions, such as MHC interactions and antibody responses to antigens. The presentation includes the structure of antibodies, particularly monoclonal IgG, and emphasizes variability in antibody residues through complementarity-determining regions (CDRs). Key processes like B cell development, immunoglobulin gene organization, class switching, and TCR rearrangement are also examined to provide a well-rounded understanding of immune responses.

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Exploring Adaptive Immunity: Key Mechanisms and Insights

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  1. Average = 77.7 = B- A = 95+ C+ = 65-71 A- = 90-94 C= 55-64 B+ = 85-89 C- =<54 B = 77-84 B- = 72-76

  2. Adaptive Immunity: 2 Branches Humoral Cell-mediated

  3. Overview of Immune System

  4. MHC interactions

  5. Response to Ag (humoral system)

  6. Response to Ag (CMI system)

  7. Electrophoresis of serum proteins

  8. Generic Ab

  9. Ribbon diagram of a monoclonal ab

  10. IgG

  11. Variability of residues in different abs. The 3 hypervariable regions are termed complementarity- determining regions (CDR)

  12. Side-view of Angiotensin II bound to Fab. Van der Waals surface contacts

  13. A peptide fomr the HIV protease with an anti-protease Fab

  14. Ab classes

  15. Antigenic determinants of Abs

  16. The Ig superfamily

  17. B cell development

  18. Organization and Expression of Ig Genes

  19. (human chromosome 22) (human chromosome 2) (human chromosome 14) Gene arrangements

  20. Circular DNA isolated from thymocytes undergoing TCR rearrangement (these rearrange just like Ab genes)

  21. From Hozumi and Tonegawa, 1976, PNAS USA 73: 3628

  22. Kappa gene expression

  23. H-gene expression

  24. Recombination signal sequences

  25. Secreted vs. membrane forms of IgM

  26. Class switching by alternative processing

  27. Class switching by alternative processing

  28. Secretory pathway

  29. When ss DNA is generated: Extra nucleotides can also be added: Nucleotide addition during joining

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