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Monash University Student Information Session

Monash University Student Information Session

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Monash University Student Information Session

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  1. Monash University Student Information Session Professor Bronwyn Kingwell

  2. 75 Commercial Road Melbourne

  3. Baker IDI mission To reduce death and disability from cardiovascular disease,diabetesand other health disorders related to obesity, through research, clinical care, education and advocacy.

  4. Metabolic and Vascular PhysiologyBronwyn Kingwell • Integrative, translational, human physiology • Combine basic bench-top & physiological techniques in humans to investigate major questions relevant to: • type 2 diabetes • coronary disease • Peripheral arterial disease • Understanding pathophysiology with a view to developing novel: • diagnostics • therapeutics

  5. Vascular Coronary disease Markers of unstable CAD Peripheral arterial disease Occlusive Aneurysmal / Marfan Metabolic & Vascular Physiology Multidisciplinary approach to discovery & translation of novel molecular mechanisms to clinical application Metabolic • HDL • Metabolic • Anti-inflammatory • Platelet Exercise mimetics Nitric oxide Brown Adipose Tissue • Epigenetic effects of high fat diet • Rabbit • Rat • Human

  6. Acute HDL Elevation(reconstituted HDL, CSL-111) • Lowers blood glucose • ↑ skeletal muscle glucose uptake (AMPK) • ↑ insulin secretion Drew et al., Circulation, 2009

  7. Primary Human Skeletal Muscle Cell Culture

  8. Human Abdominal Adipose Biopsies

  9. ? Skeletal muscle ABCA1 Other tissues Pancreas  Ca2+  insulin CaMKK AMPK • Glucose uptake • Glucose uptake HDL  Plasma glucose

  10. Current Projects • Chronic HDL elevation • Clinical trials • Human primary skeletal muscle cell culture • Additional novel pathways • Anti-inflammatory effects and insulin sensitivity • Profiling

  11. Vascular Coronary disease Markers of unstable CAD Peripheral arterial disease Occlusive Aneurysmal / Marfan Metabolic & Vascular Physiology Multidisciplinary approach to discovery & translation of novel molecular mechanisms to clinical application Metabolic • HDL • Metabolic • Anti-inflammatory • Platelet Exercise mimetics Nitric oxide Brown Adipose Tissue • Epigenetic effects of high fat diet • Rabbit • Rat • Human

  12. Brown adipose tissue WAT BAT • Release/store fat depending on demand • Low energy expenditure • Abundant in humans • Small quantity • Potentially very high energy expenditure • Not present/active in adult humans??

  13. BAT: Obesity – Why and How? • Theoretically 50gm of activated BAT could add 20% additional total basal energy expenditure 50-100g BAT

  14. Myogenic progenitors Human Muscle Novel BAT activating/differentiation factors +/- adipogenic cocktail Analysis for BAT characteristics/function BAT progenitors Current Projects • Activate BAT in obesity • Cell explants/transplants • Induce progenitor cells to form BAT

  15. Metabolic and Vascular PhysiologyProfessor Bronwyn Kingwell bronwyn.kingwell@bakeridi.edu.au www.baker.edu.au