Chemistry and Biochemistry Part 9

1. Chemistry and BiochemistryPart 9 For Advanced Diploma students of the WEA Hunter Academy of Complementary Health (c) WEA Hunter Academy of Complementary Health. Created by John Radvan. Reproduction or transmission without the express permission of the author is prohibited.

2. Chapter 16 Catabolism of macromolecules and energy generation

3. Catabolism • Means ‘breaking down’ • First Proteins, Carbohydrates and Lipids are broken down into ‘Pyruvate’ and ‘Acetyl-CoA’ • It is advisable to first follow the carbohydrate pathway to the end, then go back and look at lipids and proteins • Let’s start by examining how it all works on p185 fig 16.1

4. Glycolysis fig16.2 • The investment stage (put 2 ATP in) • Making a profit (get 4 out) • The final reckoning (sending pyruvate on) • Chat to the person next to you after reading ‘Controlling glycolysis’ – how is this process controlled? • Over the page, discover what happens to pyruvate on p188

5. The TCA Cycle • Let’s examine Fig 16.6 on p190 • The point is to examine how the Acetyl-CoA changes as it enters and goes around the cycle • During this process, what by-products are yielded?

6. The electron transport chain • Firstly, let’s look at how the electrons move, and how protons are ‘pumped’ across the membrane • Then, look at how the diffusion gradient is created, and how the ‘flowback’ creates ATP • Work with someone to read and summarise p189-192

7. Symposium! • Fats as fuel • Protein power • Just two groups this time! I HEARTSYMPOSIUMS