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Clean 100K GWAS data: 1,345 FHS family members 70,987 SNPs

Multiple related traits screen: p<0.01 in GEE or FBAT with all 3 kidney traits (CKD, cys, eGFR, n=10). n=8 SNPs. Clean 100K GWAS data: 1,345 FHS family members 70,987 SNPs. Replication: de novo genotyping of 16 SNPs in 11,447 white and 4,253 black ARIC participants.

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Clean 100K GWAS data: 1,345 FHS family members 70,987 SNPs

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  1. Multiple related traits screen: p<0.01 in GEE or FBAT with all 3 kidney traits (CKD, cys, eGFR, n=10) n=8 SNPs Clean 100K GWAS data: 1,345 FHS family members 70,987 SNPs Replication: de novo genotyping of 16 SNPs in 11,447 white and 4,253 black ARIC participants Location in a candidate gene and 1) lowest 100 p-values for each trait: ( p<0.001, n=292) or 2) two overlapping traits (CKD&eGFR, n=135; cys&eGFR, n=98) n=8 SNPs

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