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Searching the grey literature : where to look and what to expect

Searching the grey literature : where to look and what to expect. Rose Relevo, MLIS, MS Oregon Health & Sciences University Effective Healthcare Program Scientific Resource Center. Data from clinical trials. Trial Registries. Regulatory Documentation. Other misc. resources.

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Searching the grey literature : where to look and what to expect

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  1. Searching the grey literature : where to look and what to expect Rose Relevo, MLIS, MS Oregon Health & Sciences University Effective Healthcare Program Scientific Resource Center

  2. Data from clinical trials Trial Registries Regulatory Documentation Other misc. resources Conference papers, abstracts, proceedings Grey Literature

  3. Trial Registries • ClinicalTrials.gov • metaRegister of Controlled Trials (mRCT) http://www.controlled-trials.com/mrct/ • ISRCTN Register (International) • NIH ClinicalTrials.gov  • Action Medical Research (UK)  • The Wellcome Trust (UK) • Medical Research Council (UK) • UK trials (UK)

  4. Trial Registries • ClinicalStudyResults.org • PhRMA database • WHO International Clinical Trials Registry Platform Search Portal • apps.who.ing/trialsearch/ • Australia, New Zealand, US, UK, Brazil, China, India, Korea, Cuba, Germany, Iran, Japan, Pan African, Sri Lanka, The Netherlands

  5. What do you get from a trial registry • Know that a study exists • Identify forthcoming publications • Window into publication bias • Future research needs • Results • Protocols • Contact information

  6. Tips • “small” databases, searches can be simple • EndNote import filter for ClinicalTrials.gov results

  7. Regulatory Documentation • Drugs@FDA • http://www.accessdata.fda.gov/scripts/cder/drugsatfda/ • Medical and Statistical Reviews • Cannot search by class, indication or presence of review • Devices@FDA • http://www.accessdata.fda.gov/scripts/cdrh/devicesatfda/index.cfm • 510(k) Premarket Notification • Need specific device names

  8. Regulatory Documentation • Health Canada Drugs and Health Products Database • http://webprod3.hc-sc.gc.ca/dpd-bdpp/index-eng.jsp • Product Monographs • Authorized Medicines for EU • http://www.ema.europa.eu • Scientific Discussions

  9. Tips • FDA database NOT optimized for our purposes • “searching” not quite accurate, “directed browsing” more accurate • Delegate to well trained personnel • Podcasts; biggest danger is spacing out

  10. Conferences… • Conference paper databases • CSA Conference Papers Index • Scopus • BIOSIS Previews • Papers and Proceedings First • Specific conferences (key informants, technical experts)

  11. Tips • Access will vary by institution • Simple searches usually sufficient • Identify upcoming publications • Compare to published versions • Contact authors for more information

  12. Other sources • Specialized bibliographic databases • Databases to identify meetings, funders and periodicals specific to the topic • BCM Meetings • NLM Gateway – meetings • DIRLINE • COS Funding • Grantsnet • Ulrich’s • Grey Matters: a practical search tool for evidence-based medicine • http://www.cadth.ca/resources/grey-matters

  13. For more… Secure site: Resources/Grey Literature Materials relevo@ohsu.edu

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