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Non-peptide receptors. Peptide receptors. Adenosine. A1 (h). Angiotensin-II. AT1 (h). A2A (h). AT2 (h). Bombesin. bb3 (h). A2B (h). B2 (h). A3 (h). Calcitonin gene-related peptide. CGRP (h). Adrenergic. alpha 1A (h). Chemokine. CCR1 (h). alpha 2A (h). Cholecystokinin. CCKA (h).

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Peptide receptors

Non-peptide receptors

Peptide receptors

Adenosine

A1 (h)

Angiotensin-II

AT1 (h)

A2A (h)

AT2 (h)

Bombesin

bb3 (h)

A2B (h)

B2 (h)

A3 (h)

Calcitonin gene-related peptide

CGRP (h)

Adrenergic

alpha 1A (h)

Chemokine

CCR1 (h)

alpha 2A (h)

Cholecystokinin

CCKA (h)

alpha 2B (h)

CCKB (h)

alpha 2C (h)

Complement 5a

C5a (h)

beta 1 (h)

Endothelin

ETA (h)

beta 2 (h)

ETB (h)

beta 3 (h)

Galanin

GAL1 (h)

Cannabinoid

CB1 (h)

Glucagon

Glucagon (h)

CB2 (h)

Growth hormone secretagogue

Ghrelin (h)

Dopamine

D1 (h)

Melanin-concentrating hormone

MCH1 (h)

D2S (h)

MC1 (m)

D3 (h)

MC3 (h)

D4.4 (h)

MC4 (h)

GABA

GABAA (r)

Motilin

Motilin (h)

GABAB(1b) (h)

Neurokinin

NK1 (h)

BZD (central) (r)

NK2 (h)

Cl- channel (r)

Neuropeptide Y

Y1 (h)

Glutamate

AMPA (r)

Neurotensin

NT1 (h)

Kainate (r)

Opioid and opioid-like

delta 2 (h)

NMDA (r)

kappa (h)

PCP (r)

mu (h)

Glycine (strychnine-insensitive) (r)

Glycine

ORL1 (h)

Glycine (strychnine-sensitive) (r)

Somatostatin

sst4 (h)

Histamine

H1 (h)

sst5 (h)

H2 (h)

Thyroid hormone

TH (r)

Urotensin-II

UT1 (h)

H3 (h)

Vasoactive intestinal peptide

VIP1 (h)

Imidazole

I1(b)

PACAP (h)

Leukotriene

LTD4 (h)

Vasopressin

V1a (h)

Melatonin

ML1 (c)

V1b (h)

ML2 (MT3) (ham)

V2 (h)

Muscarinic

M1 (h)

Ion channels

M2 (h)

Ca2+ channels

Ca2+ channel (L, DHP site)

M3 (h)

Ca2+ channel (L, diltiazem site)

M4 (h)

M5 (h)

Ca2+ channel (L, verapamil site)

Nicotinic

N (neuronal) (α-BGTX-insensitive) (r)

Ca2+ channel (N)

N (muscle-type) (h)

Ryanodine (RY3)

Purinergic

P2X (r)

Serotonin

5-HT1A (h)

K+ channels

K+ATP channel (r)

5-HT1B (h)

K+V channel (r)

5-HT1D (r)

SK+Ca channel (r)

5-HT2A (h)

Na+ channel

Na+ channel (site 2)

5-HT2B (h) (agonist site)

5-HT2C (h)

5-HT3 (h)

Amine transporter

5-HT4e (h)

Choline

NE transporter (h)

5-HT6 (h)

Dopamine

DA transporter (h)

5-HT7 (h)

GABA

GABA transporter

sigma (non-selective) (r)

Sigma

Norepinephrine

Choline transporter (h)

5-HT transporter (h)

Seretonin

Nuclear receptors

Glucocorticoid

GR (h)

Estrogen alpha

Eralpha (h)

AR (h)

Androgen

Enzymes

Phosphodiesterases PDE2 (h)

PDE3 (h)

PDE4 (h)

PDE5 (h)

PDE6 (b)

Arachidonic acid/ COX1 (h)

prostaglandin metabolism COX2 (h)

PGE2 secretion (h)

Monoamine and neurotransmitter MAO-A (h)

synthesis and metabolism MAO-B (h)

GABA transaminase (r)

Acetylcholinesterase (h)

COMT (Catechol- O-methyl transferase) (p)

Histamine N-Methyltransferase (h)

Tyrosine hydroxylase (r)

Nitric oxide synthesis Cerebellar constitutive NOS (r)

Endothelial constitutive NOS (h)

Second messenger systems Guanylyl cyclase (b)

ATPases ATPase (Na+/K+) (d)

Lipid synthesis HMG-CoA reductase (ham)

Miscellaneous enzymes Carbonic anhydrase II (h)

Xanthine oxidase

Kinases

Phosphatases

Phospholipases

Proteases

CaMK2α (h)

ERK2 (h)

p56Fyn kinase (h)

p55Lyn kinase (h)

ZAP70 kinase (h)

Abl kinase (h)

Protein kinase C (r)

Protein kinase B-α (h)

CDK1

Phosphatase 1B (h)

Phosphatase C (r)

Elastase (h)

Tryptase (h)

ACE (h)

BACE-1 (h)

TACE (h)

HIV-1 protease (h)

ACE (h)

Neutral endopeptidase (h)

MMP-1 (h)

MMP-2 (h)

MMP-3 (h)

MMP-7 (h)

MMP-9 (h)

Cathepsin X (h)

Cathepsin L (h)

Cathepsin H (h)

Cathepsin G (h)

Cathepsin E (h)

Cathepsin D (h)

Cathepsin B (h)

m-Calpain (r)

m-Calpain (h)

Granzyme B (h)

Supplementary Table 3, Chauvier et al..2011