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EE 5393: Circuits, Computation and Biology

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  1. AND OR AND Marc D. Riedel Associate Professor, ECE University of Minnesota EE 5393: Circuits, Computation and Biology

  2. Instructor Prof. Marc Riedel tel.: (612) 625-6086email:mriedel@umn.edu office: EE/CSi4-167 office hours: M. 1:00–3:00pm

  3. Teaching Assistants YasamanAdibitel.:TBDemail:adibi002@umn.eduoffice: TBD office hours: none.

  4. EE5393: Circuits, Computation, and Biology • Lecture: Wed. & Friday, 2:30–3:45pm Location: Keller Hall 3-230 • Prereqs: none • Textbooks: none • Website: http://tinyurl.com/ee5393

  5. Grading • 20%Quizzes:11 quizzes (best 10 of 11 scores) • 80%Homeworks:5 homeworks(best 4 of 5 scores)

  6. Astonishing Hypothesis The Astonishing Part: “A person's mental activities are entirely due to the behavior of nerve cells, glial cells, and the atoms, ions, and molecules that make them up and influence them.” – Francis Crick, 1982 “That the astonishing hypothesis is astonishing.” – Christophe Koch, 1995

  7. Circuit Domains of Expertise • Vision • Language • Abstract Reasoning • Farming • Number Crunching • Mining Data • Iterative Calculations Human

  8. Circuit Brain Lousy at all the tasks that the brain that designed it is good at (including language). Circuits & Computers as a Window into our Linguistic Brains Conceives of circuits and computation by “applying” language. ?

  9. Language as a Window into the way the Brain Works Steven Pinker, Harvard

  10. Who is this guy? • Most of the cells in his body are not his own! • Most of the cells in his body are not even human! • Most of the DNA in his body isalien! “Minnesota Farmer”

  11. Who is this guy? He’s a human-bacteria hybrid: • 100 trillion bacterial cells of at least 500 different types inhabit his body. [like all of us] vs. • only 1 trillion human cells of 210 different types. “Minnesota Farmer”

  12. What’s in his gut? Who is this guy? He’s a human-bacteria hybrid: • 100 trillion bacterial cells of at least 500 different types inhabit his body. [like all of us] vs. • only 1 trillion human cells of 210 different types. “Minnesota Farmer”

  13. What’s in his gut? “E. coli, a self-replicating object only a thousandth of a millimeter in size, can swim 35 diameters a second, taste simple chemicals in its environment, and decide whether life is getting better or worse.” – Howard C. Berg About 3 pounds of bacteria! flagellum

  14. Bacterial Motor

  15. Bacterial Motor Electron Microscopic Image

  16. We should put these critters to work… “Stimulus, response! Stimulus response! Don’t you ever think!”

  17. Artificial Life Going from reading genetic codes to writing them. US Patent 20070122826 (pending):“The present invention relates to a minimal set of protein-coding genes which provides the information required for replication of a free-living organism in a rich bacterial culture medium.” – J. Craig Venter Institute

  18. Artificial Life Going from reading genetic codes to writing them. Moderator: “Some people have accused you of playing God.” J. Craig Venter:“Oh no, we’re not playing.