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This analysis explores the outcomes of patients with a history of stroke or TIA in the CURE trial, involving 506 patients without significant interaction for any outcome. It also considers data from 3,495 participants aged 75 or older with a weight of less than 60 kg, revealing no significant interactions. Furthermore, we compare findings to TRITON-TIMI 38, highlighting significant results (P<0.05). These insights, courtesy of Dr. John Eikelboom, contribute to understanding the implications of prior strokes in clinical settings.
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CURE: Prior Stroke or TIA (N=506) No significant interaction for any outcome C=clopidogrel CURE trial (unpublished data) Courtesy of Dr. John Eikelboom
CURE: Prior Stroke, Age ≥75, Weight <60 kg (N=3495) No significant interaction for any outcome CURE trial (unpublished data) Courtesy of Dr. John Eikelboom
CURE and TRITON-TIMI 38: Prior Stroke or TIA *P<0.05 CURE trial (unpublished data) Courtesy of Dr. John Eikelboom; Wiviott et al. N Engl J Med 2007;357(20):2001-15.