Oxytocin in Mammals. Pooja Iyer Francesca Gines Andy Ngo. What is oxytocin?. Released during Labor Maternal Bonding Social Recognition Pair Bonding Orgasm Also known as the “Cuddle Hormone”. Evokes feelings of: -contentment -calmness -reduces anxiety. Pituitary Gland.
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Oxytocin in Mammals PoojaIyer Francesca Gines Andy Ngo
What is oxytocin? • Released during • Labor • Maternal Bonding • Social Recognition • Pair Bonding • Orgasm • Also known as the “Cuddle Hormone” Evokes feelings of: -contentment -calmness -reduces anxiety
Pituitary Gland • Oxytocin is secreted by the pituitary gland (the master of all hormones).
Is it lipid-based or peptide based? • Oxytocin is a peptide-based hormone; it is also known as a nonapeptide because it is formed by nine amino acids.
Feedback Cycle POSITIVE FEEDBACK
Oxytocin follows a SECOND MESSENGER Second Messenger • The G-protein in this pathway is known as the OXTR protein • The protein acts as a receptor for oxytocin • Its activity is mediated by G proteins which activates several other second messenger systems • The receptors are located in the myoepithelial cells in the mammary glands and in the myometrium and endometrium of the uterus.
What is the cellular response? • Oxytocin signals • the muscle cells of the uterus to contract • Milk release during lactation
Disruptions with Oxytocin • Continuous exposure to high doses of oxytocin leads to desensitization of the receptor. • Low levels of oxytocin are thought to be a contributing factor to autism • This explains why those with autism lack in the emotional and communication department.
Works Cited • https://www.headway.org.uk/hormonal-imbalances.aspx • http://www.google.com/patents/EP1449844A1?cl=en • http://killionr.wikispaces.com/Physiology • http://www.mindfulmamma.co.uk/2012/11/birth-oxytocin/ • http://www.hindawi.com/journals/ije/2011/350546/fig1/