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Oxytocin and Resilience

Oxytocin and Resilience

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Oxytocin and Resilience

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  1. Oxytocin and Resilience

  2. Oxytocin • The “Love Hormone” • Trust • Positive feelings • Anxiolytic • Sex and pair bonding • Empathy • Produced: Hypothalamus • Released: Posterior Pituitary • Gq – PLC/IP3 pathway

  3. Traumatic

  4. Depression R=-0.58 R2=0.33 P=0.003 Anxiety R=-0.61 R2=0.37 P=0.005 Scantamburlo 07

  5. Oxytocin agonist • Used in humans • Less locomotion when given i.p.? Chaviaras 10

  6. Stress HPAaxis Cortisol

  7. Stress Hypothalamus Pituitary Adrenal Cortisol

  8. Oxytocin HPAaxis Cortisol

  9. Different Polymorphisms • Chen 2011 • Rs53576 • GG • GA • AA • Thompson 2011 • Rs2254298 • GG • GA

  10. Thompson 11 Mother with depression? Rs2254298? Hi / Low adversity + / - polymorphisim Environment x Genetics

  11. Thompson 11

  12. Receptor Polymorphism • Rs53576 • Adenosine (A) instead of a Guanine (G) • Opposite effect of adding Oxytocin • Non-coding intron mutation! • “the genetic variant investigated in this study in likely a marker for still-unidentified functional variants of the gene”

  13. Hardy-Weinberg equilibrium % Chen 11

  14. Meanwhile in Germany… Social Support NO Social Support N = 203 Chen 11

  15. Trier Social Stress for Groups Chen 11

  16. * Chen 11

  17. Chen 11

  18. Take home • Oxytocin has antidepressant/anxiolytic action • Promotes resilience • Responsible for positive effects of social support • Receptor polymorphisms appear to confer a loss of function