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Targeted Delivery of Single-Chain Antibody to Cancer Cells via Virus-Like Particles

This study presents the utilization of Virus-Like Particles (VLPs) as carriers for delivering Single-Chain Antibodies (scFv) targeting TAG-72 on cancer cells. The scFv-SRB complex is efficiently associated with the VLP, facilitating homing to cancer cells and subsequent endocytosis. The scFv-SRB cargo is released within the cytoplasm following VLP binding to the Plasma membrane, enabling specific and efficient delivery against TAG-72.

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Targeted Delivery of Single-Chain Antibody to Cancer Cells via Virus-Like Particles

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  1. Supplementary Fig. 1, Deo et al VLP-rscFv-SRB homing on cancer cell Delivery of SRB Endocytosis Plasma membrane VLP-rscFv-SRB Associated/Packaged SRB scFv against TAG-72 TAG-72 Cytoplasm

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