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Effects of Hypoxic Exposure on PAI-1 Expression and Secretion in FaDu Cells

This study investigates the influence of varying durations of hypoxic exposure on the expression and secretion levels of PAI-1 (Plasminogen Activator Inhibitor-1) in FaDu cells. Utilizing normoxic control conditions, the experiment highlights relative changes in PAI-1 expression as a function of exposure time to hypoxia, revealing a significant correlation with increased PAI-1 levels. Our findings contribute to the understanding of cellular responses to hypoxic stress and the potential implications for cancer biology.

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Effects of Hypoxic Exposure on PAI-1 Expression and Secretion in FaDu Cells

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  1. B. FaDu A. BHY * 3,5 3,5 *** *** *** 3,0 3,0 *** *** *** 2,5 2,5 *** *** *** 2,0 ** 2,0 relative PAI-1 expression relative PAI-1 expression 1,5 1,5 1,0 1,0 0,5 0,5 0,0 0,0 0 4 8 12 16 20 24 0 4 8 12 16 20 24 Time of hypoxic exposure [h] Time of hypoxic exposure [h] D. FaDu C. BHY 2,5 2,5 * hypoxia hypoxia *** normoxia normoxia 2,0 2,0 * ** *** * 1,5 1,5 * *** relative PAI-1 secretion relative PAI-1 secretion 1,0 1,0 * 0,5 0,5 0,0 0,0 0 4 8 12 16 20 24 0 4 8 12 16 20 24 Time [h] Time [h]

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