General Scheme. Some Biotinylated Chemical Moiety. Index of DNA Dumbells. Biotin labels. Addition of Streptavidin. Origami Schematic. Method. Conjugate different functional groups to selected staple strandsBind biotin to selected staple strandsVisualize formation or cleavage of individual chemical bonds by attachment or removal of biotin-streptavidin complex12 specific staples modifiedImaged under liquid in tapping mode AFM.