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Optical coherence tomography. Ting-Fang Yen. Outline. Introduction of OCT What is OCT Advantage of OCT Nowadays and future equipment Needle for OCT OCT in Nontransparent Tissue OCT application Limitation Future works Underway work Extention and application of OCT Market .

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Presentation Transcript
outline
Outline
  • Introduction of OCT
  • What is OCT
  • Advantage of OCT
  • Nowadays and future equipment
  • Needle for OCT
  • OCT in Nontransparent Tissue
  • OCT application
  • Limitation
  • Future works
  • Underway work
  • Extention and application of OCT
  • Market
introduction of oct
Introduction of OCT
  • James G. Fujimoto, 1991
  • What is OCT:

diagnostic medical imaging techonology

  • Why OCT: better diagnose and treat disease
  • Main application areas:

heart disease and cancer

what is oct optical coherence tomography
What is OCT(Optical Coherence Tomography)?
  • OCT use low-coherence interferometry to produce a two or three dimensional image of optical scattering from internal tissue microstructures.
  • Michelson interferometer is used to perform low-coherence interferometry
  • OCT measures intensity of reflected infrared light.
fundamental oct schematic
fundamental OCT Schematic

PZT

SLD

Sample

Detector

Demodulator

AD

Reference

Computer

advantage of oct
Advantage of OCT
  • Broad dynamic range,
  • High resolution
  • Rapid data acquisition rate,
  • Small inexpensive catheter/endoscope design
  • Compact portable structure

(fiber optically based, making possible the development of small catheters and endoscopes)

  • The frame rate for OCT systems are four to eight frames per second.(assume an image size of 256 by 512 pixels.)
nowadays and future equipment

FIBEROPTIC PROBE

INTEROMETER ELECTRONICS

AND

OPTICS

+COMPUTER

DISPLAY

AND

KEYBOARD

Nowadays and future equipment
  • Low-coherence Superluminescent diode:800 –1300 nm center waveength and severl milliwatts power.

Not available for salePending 510(k)

oct in nontransparent tissue
OCT in Nontransparent Tissue

B arterial layers

A epiglottis

C atherosclerotic plaques

oct application
OCT application

Esophagus & epithelium & early cancer

Vulnerable plaque

B Reduce Biopsy Hazardous

Prostate

Applied in guiding microsurgical procedure

A Reduce High False-Negative Rates

limitation
Limitation
  • Penetration: 2-3mm Ideal: 4mm
  • Resolution :

catheter/endoscope based image: 10μm, noncatheter: 4 μm,

1. femtosecond laser is expensive (1 μm)

2. transverse resolution needs to be similar to axial resolution, below 10 μm need short confocal parameter which results in the focus falling off rapidly.

  • Acquisition rate: <10franes/second
  • Lack of large-scale clinical trials
future works
Future works
  • Peneration and Resolution:

1. Need to develop with similar median wavelength, power, and bandwidth to those of the mode locked laser.

2. Need more complex catheter/ endoscope designs to alleviate the focus falling off rapidly.

  • Acquisition rates: video rate is anticipated with future embodiments.
underway work
Underway work
  • Combine OCT with Doppler velocimetry and measurement of birefringence properties.
  • The potential of giving OCT the ability to make both structural and dynamic assessments.
market
Market
  • Imalux Corporation: leader
  • total potential of OCT marketing is $2.5 billion in annual revenue
  • OCT will result in a multi-application industry similar to the path taken by ultrasound.
  • markets of gastroenterology, urology, and gynecology represent revenue potential of $781 million.
reference
Reference
  • www.afrlhorizons.wm/Briefs/Mar03/OSR0209.htm
  • http://www.lightlabimaging.com/whyoct.html
  • http://imalux.com/index.htm
  • http://www.afrlhorizons.com/Briefs/Mar03/OSR0209.html
  • http://www.3dimagery.com/michelsn.html
  • http://www.phy.duke.edu/naturalscience/reports/UseofOpt.pdf
  • D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science, vol. 254, pp.1178–1181, 1991.
  • Mark E. Brezinski and James G. Fujimoto “Optical Coherence Tomography: High-Resolution Imaging in Nontransparent Tissue“ VOL. 5, NO. 4, JULY/AUGUST IEEE 1999
  • Xingde Li, Christian Chudoba, Tony Ko, Costas Pitris, and James G. Fujimoto“Imaging needle for optical coherence tomography” Optical Letters 2000
  • J.G. Fujimoto., P, Shiung “Intraoperative Imaging Using Optical Coherence Tomography” Cth064, CLEO2002
  • J.G. Fujimoto “Optical Coherence Tomography: Technology and Application” IEEE 2002