Curtis jt and wang z neuroscience 2005 presented by yvonne pao october 31 2008
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GLUCOCORTICOID RECEPTOR INVOLVEMENT IN PAIR BONDING IN FEMALE PRAIRIE VOLES: THE EFFECTS OF ACUTE BLOCKADE AND INTERACTIONS WITH CENTRAL DOPAMINE REWARD SYSTEMS. Curtis, JT and Wang, Z. Neuroscience, 2005. Presented by: Yvonne Pao October 31, 2008. REWARD PROCESSING AND PAIR BOND FORMATION.

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Curtis jt and wang z neuroscience 2005 presented by yvonne pao october 31 2008

GLUCOCORTICOID RECEPTOR INVOLVEMENT IN PAIR BONDING IN FEMALE PRAIRIE VOLES: THE EFFECTS OF ACUTE BLOCKADE AND INTERACTIONS WITH CENTRAL DOPAMINE REWARD SYSTEMS

Curtis, JT and Wang, Z. Neuroscience, 2005.

Presented by: Yvonne Pao

October 31, 2008


Reward processing and pair bond formation
REWARD PROCESSING AND PAIR BOND FORMATION FEMALE PRAIRIE VOLES: THE EFFECTS OF ACUTE BLOCKADE AND INTERACTIONS WITH CENTRAL DOPAMINE REWARD SYSTEMS

Insel, TR 2003


Pair bonding in prairie voles
PAIR BONDING IN PRAIRIE VOLES FEMALE PRAIRIE VOLES: THE EFFECTS OF ACUTE BLOCKADE AND INTERACTIONS WITH CENTRAL DOPAMINE REWARD SYSTEMS


Neurochemicals in pair bonding
NEUROCHEMICALS IN PAIR BONDING FEMALE PRAIRIE VOLES: THE EFFECTS OF ACUTE BLOCKADE AND INTERACTIONS WITH CENTRAL DOPAMINE REWARD SYSTEMS

  • Corticosterone: adrenal stress hormone; activates glucocorticoid receptors (GR)

    • Thought to enhance reward value

  • Opposing effects in males and females:

    • Adrenalectomy in females enhancement of pair bond formation

    • Adrenalectomy in males  inhibition of pair bond formation

      Is decreased GR activation rewarding in females?


Experiment 1
EXPERIMENT 1 FEMALE PRAIRIE VOLES: THE EFFECTS OF ACUTE BLOCKADE AND INTERACTIONS WITH CENTRAL DOPAMINE REWARD SYSTEMS

  • Reduce glucocorticoid receptor activation in female prairie voles via injection

  • Pair female with male for 6 hr non-sexual habitation

  • Test females for partner preference


Experiment 11
EXPERIMENT 1 FEMALE PRAIRIE VOLES: THE EFFECTS OF ACUTE BLOCKADE AND INTERACTIONS WITH CENTRAL DOPAMINE REWARD SYSTEMS

Aragona and Wang 2008


Experiment 1 results
EXPERIMENT 1: RESULTS FEMALE PRAIRIE VOLES: THE EFFECTS OF ACUTE BLOCKADE AND INTERACTIONS WITH CENTRAL DOPAMINE REWARD SYSTEMS


Experiment 2
EXPERIMENT 2 FEMALE PRAIRIE VOLES: THE EFFECTS OF ACUTE BLOCKADE AND INTERACTIONS WITH CENTRAL DOPAMINE REWARD SYSTEMS

  • Pair bonds enhanced after GR blockade

     GR blockade is rewarding in females?

  • Hypothesis

    • GR blockade interacts with central dopamine systems (D1 and D2) of the “reward circuitry”

  • Approach

    • Pre-treat females with dopamine receptor antagonists before RU-486 treatment

    • Observe behavioral effects


Experiment 2 results
EXPERIMENT 2: RESULTS FEMALE PRAIRIE VOLES: THE EFFECTS OF ACUTE BLOCKADE AND INTERACTIONS WITH CENTRAL DOPAMINE REWARD SYSTEMS


Conclusions
CONCLUSIONS FEMALE PRAIRIE VOLES: THE EFFECTS OF ACUTE BLOCKADE AND INTERACTIONS WITH CENTRAL DOPAMINE REWARD SYSTEMS

  • Acute blockade of MRs and GRs facilitates pair bond formation in females

  • Acute reduction of GR activation increases reward value of male

  • Dopamine receptor antagonists can inhibit the effect of GR antagonists


Discussion gr blockade and pair bonding
DISCUSSION: GR BLOCKADE AND PAIR BONDING FEMALE PRAIRIE VOLES: THE EFFECTS OF ACUTE BLOCKADE AND INTERACTIONS WITH CENTRAL DOPAMINE REWARD SYSTEMS

  • Activation of GR and MRs produce opposing actions on different measures of other species

  • RU-486 and spironolactone have anti-gonadal effects

    • Enhanced pair bonding does not seem to result from these effects

  • Spironolactone treatment affects other behaviors

    • Suggests it acts centrally

    • Greatest concentration of MR found in hippocampus, which may alter activity of ventral tegmental area (VTA)


Discussion gr interaction with dopamine
DISCUSSION: GR INTERACTION WITH DOPAMINE FEMALE PRAIRIE VOLES: THE EFFECTS OF ACUTE BLOCKADE AND INTERACTIONS WITH CENTRAL DOPAMINE REWARD SYSTEMS

  • D1 and D2 blockade antagonizes GR blockade by RU-486

  • Effects of D1 receptor blockade were unexpected:

    • Previous studies indicate D1 blockade does not interfere with mating-induced partner preference

    • Mating and pair bonding involve different mechanisms?

  • Effects of D2 receptor were expected:

    • Has been found to play major role in pair bonds

    • Social stress alters dopamine release in NAcc (also implicated in prairie vole pair bonding)

       Corticosterone interact with dopamine in NAcc