Brian Corry Summer 2012/13

1. Choosing Contexts and Experiments that Help Students Make Connections in ChemistryRET Program Summary Brian Corry Summer 2012/13

2. Designing Curriculum Units that Help Students Make Connections in ChemistryRET Program Summary Brian Corry Summer 2012/13

3. My background • Arrowhead High School • Hartland, WI • AP Chemistry • General Physics and AP Physics • Procter & Gamble • Cincinnati, OH • Researcher, Drying and Particle Formation • University of Illinois • Champaign, IL • BS Chemistry

4. Presentation Outline • Summary of RET Experiences and Research • Connecting the research to chemistry education / instructional model • Design criteria for curriculum that helps students make connections • Curriculum Unit Example

5. RET Program • Research Experience for Teachers • University of Wisconsin – Milwaukee • Supported by NSF • Objective: collaborate with MS / HS science teachers to improve the quality of science education

6. My Faculty Mentor • Dr. Alan Schwabacher • UWM • PhD, Columbia • Organic Chemistry • Research focuses on mimicking the selective binding of biological molecules

7. Catalyzed Hydrolysis of BNPP Chem 582 at UWM

8. Slow Cu2+, Fast p-nitrophenol bis(p-nitrophenyl) phosphate (BNPP) bis(p-nitrophenyl) phosphate (BNPP) p-nitrophenol

9. Michaelis-Menten Kinetics Cu2+, Fast bis(p-nitrophenyl) phosphate (BNPP) p-nitrophenol

10. Hydrolysis of a phosphate diester Hydrolysis of BNPP

11. Phosphate diesters are extremely important biologically

12. pKa2 = 4.96 pKa1 = 0.30 pKa = 2.79 Catalyst? Rate Hydrolysis of a phosphate diester Hydrolysis of BNPP pKa = 7.16 Biochemistry Kinetics / Catalysis Acid / Base Yellow

14. pKa2 = 4.96 pKa1 = 0.30 pKa = 2.79 Catalyst? Rate Hydrolysis of a phosphate diester Hydrolysis of BNPP pKa = 7.16 Biochemistry Analytical / Spectroscopy Kinetics / Catalysis Acid / Base Yellow

15. Synthesis of TNPP 10 g BNPP = $315 10 g NaBNPP = $1500 Synthesis of BNPP Hydrolysis of BNPP Biochemistry Analytical / Spectroscopy Kinetics / Catalysis Acid / Base

16. TNPP 50 g = $27 1st time: 53% yield 2nd time: 70% yield 250 g = $36 BNPP 1st time: 46% yield 2nd time: 52% yield $400

17. Hydrolysis of BNPP Biochemistry Analytical / Spectroscopy Kinetics / Catalysis Acid / Base

18. Extraction / Purification TLC / Polarity Organic Synthesis NMR / Characterization Synthesis of TNPP/BNPP Hydrolysis of BNPP Biochemistry Analytical / Spectroscopy Kinetics / Catalysis Acid / Base

19. Absorbance is directly proportional to [PNP] = Beer’s Law

20. We can monitor the progress of reactions.

21. Rate is not first order… …if you ignore ionic strength.

22. Rate is first order with respect to hydroxide.

23. Rate is first order with respect to BNPP.

24. A catalyst increases the rate of reaction.

25. Outcomes • Chemistry 582 • More effective synthetic route for BNPP • Students make their own reagents • Michaelis-Menten kinetics (not yet?) • AP Chemistry • Access to expensive materials • Phosphate esters • PNP in Beer’s Law activity • BNPP to study kinetics/catalysis

26. Classroom vs. Research Lab

27. Classroom vs. Research Lab

28. Classroom vs. Research Lab

29. Classroom vs. Research Lab

30. Classroom vs. Research Lab

31. Classroom vs. Research Lab

32. Classroom vs. Research Lab

33. “When a school subject is taught for which there is a professional counterpart, there should be a conceptual connection to post-secondary studies and to the practice of that subject in the real world.” • National Research Council. (2009). Engineering in K-12 education: Understanding the status and improving the prospects. Washington, DC: The National Academies Press.

34. Standard Chemistry Education Unit 1 Unit 2 Unit 3 Unit 4 Structure Content Content Content Content Context Context Context Context Chemistry Expected Outcome Content / Context

35. Standard Chemistry Education Unit 1 Unit 2 Unit 3 Unit 4 Structure Content Content Content Content Context Context Context Context Unit 1 Unit 2 Unit 3 Unit 4 Actual Outcome Content Content Content Content Context Context Context Context

36. “Your system is perfectly designed to give you the results you're getting.” • W. Edwards Deming

37. Which outcome do we want? Unit 1 Unit 2 Unit 3 Unit 4 Outcome 1 Content Content Content Content Context Context Context Context Chemistry Outcome 2 Content / Context

38. Unit Expectations Unit 1 Unit 2 Unit 3 Unit 4 Structure Content Content Content Content Context Context Context Context Chemistry Expected Outcome Content / Context

39. Course Expectations Unit 1 Unit 2 Unit 3 Unit 4 Structure Content Content Content Content Context Context Context Context Chemistry Expected Outcome Content / Context

40. Alternative Model Unit 1 Unit 2 Unit 3 Unit 4 Structure Content Content Content Content Context Chemistry Expected Outcome Content / Context

41. Alternative Model Unit 1 Unit 2 Unit 3 Unit 4 Structure Content Content Content Content Context Chemistry Expected Outcome Content / Context

42. Alternative Model Unit 1 Unit 2 Unit 3 Unit 4 Structure Content Content Content Content Context Chemistry Expected Outcome Content / Context

43. Important Design Consideration Unit 1 Unit 2 Unit 3 Unit 4 Structure Content Content Content Content Context Chemistry Expected Outcome Content / Context

44. Important Instructional Consideration Unit 1 Unit 2 Unit 3 Unit 4 Structure Content Content Content Content Context Chemistry Expected Outcome Content / Context

45. http://chemistry.beloit.edu/modules.html These 2-4-week modules start with relevant real-world questions and develop the chemistry needed to answer them. In the process, students model how chemistry is actually done and discover connections between chemistry and other sciences, technology, and society.

46. Other curriculum materials ACS CLUE Living by Chemistry

47. 3 Important Design Criteria

48. AP Chemistry “Big Ideas”

49. AP Chemistry “Big Ideas” 1 2 3 4 5 6