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Motor neuron disease. Motor Neurone Disease. Definition: It is a degenerative disease of a gradual onset and progressive course, affecting the motor system only (systemic disease). (corticospinal tract+ anterior horn cell) UMN signs LMN signs. Motor neuron disease.

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motor neurone disease
Motor Neurone Disease
  • Definition:

It is a degenerative disease of a gradual onset and progressive course, affecting the motor system only (systemic disease).

clinical picture
Clinical Picture
  • Age of onset:
  • Sex:
  • Onset and Course:
  • Signs and symptoms:
i u m n affection
I-U.M.N. Affection
  • a) In the spinal cord:
  • Spastic paraplegia if the lesion is below the cervical region, or
  • Spastic quadriplegia if the lesion is at the cervical region.
slide6
b)In the brain stem or the cerebral hemisphere:

1.Bulbar symptoms:

- dysphagia. - nasal regurgitation.

- dysarthria. - hoarseness of voice.

motor neurone disease1
Motor Neurone Disease

I- U.M.N.L.

II- L.M.N.L.

a-Brain Stem

“True Bulbar

Palsy

a-Brain Stem

“Pseudo-bulbar palsy

b-Spinal Cord

“Progressive Muscular Atrophy”

b-Spinal Cord

“Lateral Sclerosis

iii combined u m n and l m n affection
III-Combined U.M.N and L.M.N Affection

Syndrome of :

"amyotrophic lateral sclerosis“

There are combined signs and symptoms of lower and upper motor neurone lesions

diagnosis
Diagnosis
  • ALS is difficult to diagnose because it has similar symptoms of other neuromuscular disorders. Some of the procedures include:

Magnetic resonance imaging (MRI)

slide14
1- Avoid fatigue and exhaustion.

2- Massive doses of vit. E and B.

3- Anabolics.

4-Physiotherapy,respiratory care,swallowing,….

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