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Synthesis and structural analysis of functional oligosaccharides

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Novel Technologies to assess Gut Health Claims for Carbohydrates Subthema 1: Synthesis and structural analysis of functional oligosaccharides Name: Prof. Dr. Lubbert Dijkhuizen Affiliation: University of Groningen/ Microbiology Contact: L.Dijkhuizen@rug.nl.

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Novel Technologies to assess Gut Health Claims for Carbohydrates Subthema 1: Synthesis and structural analysis of functional oligosaccharidesName: Prof. Dr. Lubbert DijkhuizenAffiliation: University of Groningen/ MicrobiologyContact: L.Dijkhuizen@rug.nl

synthesis and structural analysis of functional oligosaccharides
Synthesis and structural analysis of functional oligosaccharides

State of the art:AvailabilityCharacterized

Fructo-, Galacto-, (Iso)Malto- + +?

Xylose-, Pectin-, Mannan-, Chito- (+) (+)??

Glucose1,2-1,3-1,4; IMO-MALT (+) -

Glucansucrase acceptor products (+) -

Plant cell wall oligo’s (+)-

Human Milk oligo’s (+) -

“CCC new oligo’s” - -

synthesis and structural analysis of functional oligosaccharides1
Synthesis and structural analysis of functional oligosaccharides

New technologies:

Enzyme discovery and engineering:

synthesis of tailor-made oligo’s:

monosaccharides, linkages

Structural analysis:

In vitro: newly synthesized oligo’s

In gut: modification, degradation, during passage