1 / 8

Terminology

HIV Human Immunodeficiency Virus. AIDS Acquired Immune Deficiency Syndrome. Terminology. Classification of HIV. 2 types of HIV: HIV – 1 (>99%) HIV - 2. Genetic forms of HIV - 1. some phylogenetic subgroups :

cshelby
Download Presentation

Terminology

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. HIV Human Immunodeficiency Virus AIDS Acquired Immune Deficiency Syndrome Terminology

  2. Classification of HIV 2 types of HIV: HIV – 1 (>99%) HIV - 2

  3. Genetic forms of HIV - 1 somephylogeneticsubgroups: M (main) 9 subtypes (A – D, F – H, J i K) O (outlier) (rare) N (novel) (rare) P CRF (CirculatingRecombinantForms)

  4. Replication cycle of HIV - Viralgp 120 binds to CD4 receptor of a lymphocyte • Coreceptors for entry: CCR5 or CXCR4 arehelpful • Fusion of HIV withcellularmembrane of lymphocyteoccurs – virusentersthecell • Viral RNA isconverted (transcripted) into DNA by reversetranscriptase • HIV DNA (provirus) integrateswith DNA of a lymphocyte • RNA copies of a provirusaremade (mRNA) – transcription • mRNAistransported to thecytoplasm and makesthe host cellproduce long chains of viral protein (translation) • HIV core protein and genomic RNA gatherinsidethecell and immatureviralparticles form and bud offfromthecell • Chain of viral protein iscutintopieces by protease. Thatresultsin forming infectiousviralparticles.

  5. Targets of HIV Therapy Integrase Inhibitors Entry Inhibitors: Fusion, CD4, CCR5 CXCR4 Nucleus RNA Protease DNA Reverse transcriptase HIV CD4+ T-Cell Reverse transcriptase inhibitors: NRTI (nucleosides, nucleotides) NNRTI Protease inhibitors

More Related