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Understanding the Intersection Between Information Technology and the Life Sciences The Terrain

Understand the convergence of Information Technology and Life Sciences at the Bio-IT Workshop. Explore the future of genomics, bioinformatics, and data management with industry insights and expert perspectives.

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Understanding the Intersection Between Information Technology and the Life Sciences The Terrain

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  1. Understanding the Intersection Between Information Technology and the Life SciencesThe Terrain Bob RoyceVP Business Development Bio-IT Workshop: Positioning Your Firm. January 21, 2003

  2. I want to conquer death! I don’t want to be sick! Bio-IT Workshop: Positioning Your Firm. January 21, 2003

  3. What is Bio-IT? Information Technology Life Sciences Bio-IT Workshop: Positioning Your Firm. January 21, 2003

  4. “Biology is an information science” Leroy Hood, Michigan Life Science Core Technology Alliance Inauguration In vivo In silico Bio-IT Workshop: Positioning Your Firm. January 21, 2003

  5. “the language of biologyis sounding increasingly like the language of systems engineering ” MIT President Chuck Vest 103 of 341 MIT engineering school faculty use the term “bio” to describe the nature of their research. Systems Biology at MIT: It’s All Over the Place By Adrienne Burke, Genome Technology editor-in-chief CAMBRIDGE, Mass., Jan. 9 Bio-IT Workshop: Positioning Your Firm. January 21, 2003

  6. Biological Information Genotype -> Phenotype Biological Function DNA Scientific Process Information Hypothesis -> Experiment Analysis Design Optimization/Archive Bio-IT Workshop: Positioning Your Firm. January 21, 2003

  7. Adenine Thymine Cytosine Guanine DNA: Where it all starts The ultimate compression algorithm A 4 letter code, 3 billion letters long… … contains the recipe for building you and me Bio-IT Workshop: Positioning Your Firm. January 21, 2003

  8. Bioinformatics Sequence Analysis Chemical DB’s, Combinatorial Chemistry, Docking studies Computational Chemistry and Protein Folding Homology Modeling Genomics to Proteomics Bio-IT Workshop: Positioning Your Firm. January 21, 2003

  9. From Genotype to Phenotype Bio-IT Workshop: Positioning Your Firm. January 21, 2003

  10. Complex, Deeply Nested Layers of Data Bio-IT Workshop: Positioning Your Firm. January 21, 2003

  11. All this Produces an Information Explosion Bio-IT Workshop: Positioning Your Firm. January 21, 2003

  12. …That must be managed in a both a Public and Private Context Data Domain no direct control of data format Public Partnerships/ Collaborations moderate control of data format Future Present Past high level of control of data format Internal Static Dynamic Data Type Bio-IT Workshop: Positioning Your Firm. January 21, 2003

  13. Bio-IT Workshop: Positioning Your Firm. January 21, 2003

  14. “In 50 percent of the interactions that I have with vendors, they say, ‘We have a great technology that can help you….Now tell me about drug discovery ’ ” “There does seem to be a disconnect between the value proposition and what is offered,” Rainer Fuchs, vice president of research informatics at Biogen Shawn Ramer, vice president of R&D informatics at Bristol-Myers Squibb Bio-IT Workshop: Positioning Your Firm. January 21, 2003

  15. $800 M Fully Capitalized Cost to develop $350 M Sales Avg. per year Blockbusters (>$1B) Carry the rest...e.g. Lipitor Pharmaceutical R&D Bio-IT Workshop: Positioning Your Firm. January 21, 2003

  16. Pharmaceutical R&D Bio-IT Workshop: Positioning Your Firm. January 21, 2003

  17. Conclusion • Current focus is on applied technology… • Must understand the drug discovery process. • Complexity of industry should not be underestimated • Pace of discovery and innovation is staggering • Partnerships and alliances are key • Nobody has the “right” model…. • Everybody knows they need new ways to solve the problem • Fragmentation in solution space makes it difficult to get economies of scale for technology development • But the goal is noble and the prize is large! Bio-IT Workshop: Positioning Your Firm. January 21, 2003

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