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Fenofibrate Induces mThA and mThB in Mouse Liver and Intestine

Fenofibrate treatment alters peroxisomal thiolase A (mThA) and thiolase B (mThB) fold induction in the liver and intestine of mice. The relative proportions and fold inductions are compared to untreated liver samples.

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Fenofibrate Induces mThA and mThB in Mouse Liver and Intestine

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  1. a) b) c ) liver l iver intestine kidney WAT liver Fenofibrate ARN (µg) 1 2 5 10 Mouse peroxisomal mThA mThA thiolase A (mThA) Fold induction X 1 X 1.6 % mThA relative to liver 1 00% 50% 80% 50% Relative proportion 61% mThB Mouse peroxisomal mThB thiolase B (mThB) Fold induction X 1 X 10 % mThB relative to liver 100% 40% 10% 10% Relative proportion 39% 36B4 36B4 (P0)

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