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  1. A BxPC-3 HeLa MEK1 inhibitor + + aVb6 antibody + + TGFb1 RII antibody + + + TGFb1 - + + + + - + + + + + p130Cas SOS1/2 pp125FAK HeLa BxPC-3 + - latent TGF-b1 B C - + mature TGF-b1 p125FAK latent TGF-b1 SMAD4 mature TGF-b1