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  1. MCF-7 MDA-MB 231 + MEK1 inhibitor + + + aVb6 antibody + + + + TGFb1-RII antibody + + - + + + + + TGFb1 - + + + + + p21Ras* 10 min ERK 1/2-P c-jun c-fos 6 h p21WAF1 p27Kip PCNA 130 kDa 10 min p-Y 90 kDa