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MCF-7 MDA-MB 231. + MEK1 inhibitor +. + + a V b 6 antibody + +. + + TGF b 1-RII antibody + +. - + + + + + TGF b 1 - + + + + +. p21 Ras *. 10 min. ERK 1/2-P. c-jun. c-fos. 6 h. p21 WAF1. p27 Kip. PCNA. 130 kDa. 10 min. p-Y. 90 kDa.
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MCF-7 MDA-MB 231 + MEK1 inhibitor + + + aVb6 antibody + + + + TGFb1-RII antibody + + - + + + + + TGFb1 - + + + + + p21Ras* 10 min ERK 1/2-P c-jun c-fos 6 h p21WAF1 p27Kip PCNA 130 kDa 10 min p-Y 90 kDa